Children of today will need opportunities to develop a disposition towards learning that will
empower them throughout their life to be proactive seekers of knowledge–life-long learners–…

Background Colon cancer has been classically described by clinicopathologic features that
permit the prediction of outcome only after surgical resection and staging. Methods We …

Purpose Aberrant Notch signaling has been implicated in the pathogenesis of many human
cancers. MK-0752 is a potent, oral inhibitor of-secretase, an enzyme required for Notch …

Purpose: Investigate the efficacy and pharmacodynamic effects of MK-1775, a potent Wee1
inhibitor, in both monotherapy and in combination with gemcitabine (GEM) using a panel of …

In this article we explore young children's development of mathematical knowledge and
reasoning processes as they worked two modelling problems (the Butter Beans Problem and …

Background: Adverse events are poor patient outcomes that are due to medical care. Studies
of hospital patients have demonstrated that adverse events are common, but few data …

Objective The authors set out to determine whether immediate enteral feeding minimizes
early postoperative decreases in handgrip and respiratory muscle strength. Summary …

Patients with FGFR2 -driven cancers derive limited benefit from pan-FGFRi due to multiple
FGFR1–4-mediated toxicities and acquired FGFR2 resistance mutations. RLY-4008 is a …

This paper addresses the first year of a three-year, longitudinal study which introduces
mathematical modeling to young children and provides professional development for their …

Background Spontaneous tumors in dog have been demonstrated to share many features
with their human counterparts, including relevant molecular targets, histological appearance, …