A nonparametric approach to pricing and hedging derivative securities via learning networks

JM Hutchinson, AW Lo, T Poggio - The journal of Finance, 1994 - Wiley Online Library
We propose a nonparametric method for estimating the pricing formula of a derivative asset
using learning networks. Although not a substitute for the more traditional arbitrage‐based …

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

…, PN Harden, P Reinke, A Moreau, JA Hutchinson… - The Lancet, 2020 - thelancet.com
Background Use of cell-based medicinal products (CBMPs) represents a state-of-the-art
approach for reducing general immunosuppression in organ transplantation. We tested multiple …

Novel polymorphisms in the promoter and 5′ UTR regions of the human vascular endothelial growth factor gene

…, K Isaac, JA Hutchinson, V Pravica, IV Hutchinson - Human immunology, 1999 - Elsevier
We have characterized 5 novel, single-nucleotide polymorphisms in the promoter and 5′
UTR regions of the human vascular endothelial growth factor (VEGF) gene. Transitions C → A …

Health Care-Associated Clostridium difficile Infection in Canada: Patient Age and Infecting Strain Type Are Highly Predictive of Severe Outcome and Mortality

…, M Gardam, A McGeer, J Hutchinson… - Clinical Infectious …, 2010 - academic.oup.com
Background C. difficile infection (CDI) has become an important and frequent nosocomial
infection, often resulting in severe morbidity or death. Severe CDI is more frequently seen …

Health Care-Associated Clostridium difficile Infection in Adults Admitted to Acute Care Hospitals in Canada: A Canadian Nosocomial Infection Surveillance Program …

…, M Gardam, A McGeer, J Hutchinson… - Clinical Infectious …, 2009 - academic.oup.com
Background. Clostridium difficile infection (CDI) is the most frequent cause of health care-associated
infectious diarrhea in industrialized countries. The only previous report describing …

Cutting edge: immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients

JA Hutchinson, P Riquelme, B Sawitzki… - The Journal of …, 2011 - journals.aai.org
Regulatory macrophages (M regs) were administered to two living-donor renal transplant
recipients. Both patients were minimized to low-dose tacrolimus monotherapy within 24 wk of …

[HTML][HTML] Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study

…, MR Reed, R Magari, EK Geissler, JA Hutchinson… - Transplantation …, 2013 - Springer
Background Immune monitoring by flow cytometry is a fast and highly informative way of
studying the effects of novel therapeutics aimed at reducing transplant rejection or treating …

Computing motion using analog and binary resistive networks

J Hutchinson, C Koch, J Luo, C Mead - Computer, 1988 - ieeexplore.ieee.org
The authors describe recent developments in the theory of early vision that led from the
formulation of the motion problem as an ill-posed one to its solution by minimizing certain 'cost' …

Hurdles in therapy with regulatory T cells

…, C Hilkens, JA Hutchinson… - Science translational …, 2015 - science.org
Improper activation of the immune system contributes to a variety of clinical conditions,
including autoimmune and allergic diseases as well as solid organ and bone marrow …

[HTML][HTML] IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients

…, F Fändrich, HJ Schlitt, EK Geissler, JA Hutchinson - Molecular Therapy, 2013 - cell.com
Mouse monocytes exposed to macrophage colony-stimulating factor (M-CSF) and interferon-γ
(IFN-γ) were driven to a novel suppressor phenotype. These regulatory macrophages (M …