Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent
colitis. Here, we show that interleukin-17A (IL-17A)-producing IL-7Rα + innate …

Background and aim Thymus-derived regulatory T cells (T regs ) mediate dominant peripheral
tolerance and treat experimental colitis. T regs can be expanded from patient blood and …

T reg cells are critical for the prevention of autoimmune diseases and are thus prime candidates
for cell‐based clinical therapy. However, human T reg cells are “plastic”, and are able to …

Results Both groups had similar total regulatory T cells and subpopulations I and III. In each
subpopulation, regulatory T cells expressed similar levels of the function-associated markers …

Background & Aims Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal
inflammatory cells that participate in chronic intestinal inflammation. We investigated the role of …

Low-grade inflammation in fat is associated with insulin resistance, although the mechanisms
are unclear. We report that mice deficient in the immune cell transcription factor T-bet have …

Regulatory T cells (CD4 + CD25 hi CD127 lo FOXP3 + T cells [Tregs]) are a population of
lymphocytes involved in the maintenance of self-tolerance. Abnormalities in function or …

Background: Efficacy data from adult ulcerative colitis (UC) clinical trials are often
extrapolated for pediatric prescribing. Consequently, it is important to understand similarities/…

Objective To prospectively assess the cost of patients in an adult intensive care unit (ICU)
using bottom-up costing methodology and evaluate the usefulness of “severity of illness” …

Artificial intelligence shows promise for clinical research in inflammatory bowel disease
endoscopy. Accurate assessment of endoscopic activity is important in clinical practice and …