Characteristics of the M Cell. The discovery and characterization of the M cell, a unique cell
type residing in the deep layers of the ventricular myocardium, has opened a new door in our …

Transmural Dispersion of Repolarization In Vivo. Introduction: In vitro studies have provided
evidence for the existence of M cells. The present study examines the contribution of the M …

Aims Obesity can modify the pharmacokinetics of lipophilic drugs. As β‐adrenoceptor blockers
(BB) are often prescribed for obese patients suffering from hypertension or coronary heart …

OBJECTIVES: The arrhythmogenic and electrophysiologic properties of sotalol, a class III
antiarrhythmic drug, administered alone and in combination with mexiletine, a class I …

The σ 2 -receptor agonist, ifenprodil, was suggested as an inhibitor of G protein-coupled
inwardly rectifying potassium channels. Nevertheless, an analysis of the role of σ 2 receptors in …

Objective: The present study was designed to examine the effects of chronic amiodarone on
the different ventricular cell subtypes in situ and to evaluate its interactions with sotalol. …

At supratherapeutic doses (2- to 5-fold), the T-type Ca 2+ antagonist mibefradil modifies the
T/U wave of the human ECG. In this study, we show that this effect is observed in conscious …

Droperidol and ondansetron are potent anti‐emetic agents which are often administered
together. Although both drugs prolong QT interval in man by inhibition of Human Ether‐a‐go‐…

A group of 36 patients in the hematology department of Saint-Antoine Hospital, Paris, France,
was on chemotherapy. The patients were also given antiacid drugs to prevent …

Sotalol Plus Quinidine and Torsades de Pointes. Introduction: Clinical treatment with a
combination of Class IA and III antiarrhythmic drugs is not recommended, as they both favor …