Purpose of review Patients with type 1 diabetes (T1D) are typically viewed as lean individuals.
However, recent reports showed that their obesity rate surpassed that of the general …

Cell cycle quiescence is a critical feature contributing to haematopoietic stem cell (HSC)
maintenance. Although various candidate stromal cells have been identified as potential HSC …

Discrete event simulation (DES) is a form of computer-based modeling that provides an
intuitive and flexible approach to representing complex systems. It has been used in a wide …

Genotypic differences greatly influence susceptibility and resistance to disease.
Understanding genotype–phenotype relationships requires that phenotypes be viewed as …

Single-cell gene expression analyses of mammalian tissues have uncovered profound
stage-specific molecular regulatory phenomena that have changed the understanding of unique …

It has been proposed that the plasma phospholipid transfer protein (PLTP) facilitates the
transfer of phospholipids and cholesterol from triglyceride-rich lipoproteins (TRL) into high-…

A single hematopoietic stem cell (HSC) is capable of reconstituting hematopoiesis and
maintaining homeostasis by balancing self-renewal and cell differentiation. The mechanisms of …

The economic evaluation of health technologies has become a major tool in health policy in
Europe for prioritizing the allocation of health resources and the approval of new …

The stress singularity at the tip of a crack, either lying along or perpendicular to the interface
of the two materials, is first investigated by the complex variable method. The order of the …

Somatic cell reprogramming to a pluripotent state continues to challenge many of our
assumptions about cellular specification, and despite major efforts, we lack a complete molecular …