Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost universally. …

Advances in genomics, proteomics and molecular pathology have generated many candidate
biomarkers with potential clinical value. Their use for cancer staging and personalization …

Distinct classes of small RNAs, 20–32 nucleotides long, play important regulatory roles for
diverse cellular processes. It is therefore important to identify and quantify small RNAs as a …

An accessible introduction to quantitative methods in community ecology, with related
software. Provides a thoughtful overview on the nature of data collection, followed by detailed …

A comment on this article appears in" Fatty liver disease: turning the tide." Nature. 2017 Oct
11; 550 (7675): S101. A comment on this article appears in" Treating NASH." J Gastroenterol …

Can machine learning improve human decision making? Bail decisions provide a good test
case. Millions of times each year, judges make jail-or-release decisions that hinge on a …

The OPAL detector at thc c* c storage ring I. EP is designed to providc prccisc mcasu remonts
of charged particles and of clcctromagnetic cncrgy over ncarly the full solid angle. Its main …

Background The question of whether neighborhood environment contributes directly to the
development of obesity and diabetes remains unresolved. The study reported on here uses …

In vitro–transcribed mRNAs encoding physiologically important proteins have considerable
potential for therapeutic applications. However, in its present form, mRNA is unfeasible for …

The expansion of publicly-funded preschool education is currently the focus of a prominent
debate. At present, 42% of 4-year-olds attend publicly funded preschool (28% attend public …