BACKGROUND Anemia is common in cancer patients, although the prevalence is influenced
both by the type of malignancy and the choice of treatment. Individual studies have …

Models—mathematical frameworks that facilitate estimation of the consequences of health
care decisions—have become essential tools for health technology assessment. Evolution of …

Patient-reported outcomes (PROs), such as symptoms, health-related quality of life (HRQOL),
or patient perceived health status, are reported directly by the patient and are powerful …

Background Budget impact analyses (BIAs) are an essential part of a comprehensive
economic assessment of a health care intervention and are increasingly required by …

Trust and confidence are critical to the success of health care models. There are two main
methods for achieving this: transparency (people can see how the model is built) and …

Background: Clinical trials have demonstrated that drug therapy can reduce osteoporosis-related
fracture risk in women over 50 years of age. Noncompliance could considerably limit …

Discrete event simulation (DES) is a form of computer-based modeling that provides an
intuitive and flexible approach to representing complex systems. It has been used in a wide …

BACKGROUND: Despite the existence of efficacious medications, many patients in actual
practice remain with uncontrolled hypertension. Randomized clinical trials, cannot address …

Objective.To estimate the clinical and economic burden of Clostridium difficile-associated
disease (CDAD) in Massachusetts over 2 years.Design.A retrospective analysis of …

OBJECTIVE:: To evaluate non-compliance with osteoporosis medications as well as its
implications for health and economic outcomes in actual practice. STUDY DESIGN:: Data on …