User profiles for J. David Spence
 | J. David SpenceRobarts Research Institute, University of Western Ontario Verified email at robarts.ca Cited by 45040 |
Grapefruit juice–drug interactions
…, J Malcolm, O Arnold, J David Spence - British journal of …, 1998 - Wiley Online Library
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was
based on an unexpected observation from an interaction study between the dihydropyridine …
based on an unexpected observation from an interaction study between the dihydropyridine …
[HTML][HTML] Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis
…, KE Thorpe, HE Meldrum, JD Spence - … England Journal of …, 1998 - Mass Medical Soc
Background Previous studies have shown that carotid endarterectomy in patients with
symptomatic severe carotid stenosis (defined as stenosis of 70 to 99 percent of the luminal …
symptomatic severe carotid stenosis (defined as stenosis of 70 to 99 percent of the luminal …
[HTML][HTML] Atrial fibrillation in patients with cryptogenic stroke
…, DJ Sahlas, P Teal, S Yip, JD Spence… - … England Journal of …, 2014 - Mass Medical Soc
Background Atrial fibrillation is a leading preventable cause of recurrent stroke for which
early detection and treatment are critical. However, paroxysmal atrial fibrillation is often …
early detection and treatment are critical. However, paroxysmal atrial fibrillation is often …
Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention …
JF Toole, MR Malinow, LE Chambless, JD Spence… - Jama, 2004 - jamanetwork.com
ContextIn observational studies, elevated plasma total homocysteine levels have been
positively associated with ischemic stroke risk. However the utility of homocysteine-lowering …
positively associated with ischemic stroke risk. However the utility of homocysteine-lowering …
Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
GK Dresser, JD Spence, DG Bailey - Clinical pharmacokinetics, 2000 - Springer
Drug interactions occur when the efficacy or toxicity of a medication is changed by administration
of another substance. Pharmacokinetic interactions often occur as a result of a change …
of another substance. Pharmacokinetic interactions often occur as a result of a change …
[HTML][HTML] Pioglitazone after ischemic stroke or transient ischemic attack
…, P Ringleb, S Sen, JD Spence… - … England Journal of …, 2016 - Mass Medical Soc
Background Patients with ischemic stroke or transient ischemic attack (TIA) are at increased
risk for future cardiovascular events despite current preventive therapies. The identification …
risk for future cardiovascular events despite current preventive therapies. The identification …
[HTML][HTML] Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke
Background The efficacy of closure of a patent foramen ovale (PFO) in the prevention of
recurrent stroke after cryptogenic stroke is uncertain. We investigated the effect of PFO closure …
recurrent stroke after cryptogenic stroke is uncertain. We investigated the effect of PFO closure …
Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial
…, V Hachinski, GP Clagett, R Barnes, JD Spence - The Lancet, 1999 - thelancet.com
Background Endarterectomy benefits certain patients with carotid stenosis, but benefits are
lessened by perioperative surgical risk. Acetylsalicylic acid lowers the risk of stroke in …
lessened by perioperative surgical risk. Acetylsalicylic acid lowers the risk of stroke in …
Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy
JD Spence, M Eliasziw, M DiCicco, DG Hackam… - Stroke, 2002 - Am Heart Assoc
Background and Purpose— Carotid plaque area measured by ultrasound (cross-sectional
area of longitudinal views of all plaques seen) was studied as a way of identifying patients at …
area of longitudinal views of all plaques seen) was studied as a way of identifying patients at …
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving …
…, JAE Manson, KH Bønaa, JD Spence… - Archives of internal …, 2010 - jamanetwork.com
Elevated plasma homocysteine levels have been associated with higher risks of cardiovascular
disease, but the effects on disease rates of supplementation with folic acid to lower …
disease, but the effects on disease rates of supplementation with folic acid to lower …