Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury

J Villar, JD Edelson, M Post, JBM Mullen… - American Review of …, 1993 - atsjournals.org
This study examined the hypothesis that transient, whole-body hyperthermia would reduce
lung damage and/or mortality in a previously described animal model of acute lung injury. …

Alkaline Phosphatase: A Marker of Alveolar Type II Cell Differentiation1, 2

JD Edelson, JM Shannon, RJ Mason - Am. Rev. Respir. Dis, 1988 - atsjournals.org
In an effort to identify type II cells by a method independent of staining phospholipid inclusions,
we evaluated a histochemical technique for alkaline phosphatase activity In normal rat …

Sodium arsenite induces heat shock protein-72 kilodalton expression in the lungs and protects rats against sepsis

SP Ribeiro, J Villar, GP Downey, JD Edelson… - Critical care …, 1994 - journals.lww.com
Objective: To examine the hypothesis that induction of heat shock proteins by a non-thermal
mechanism would confer protection against experimental sepsis. Design: Prospective, blind…

Effects of the stress response in septic rats and LPS-stimulated alveolar macrophages: evidence for TNF-alpha posttranslational regulation.

…, J Villar, GP Downey, JD Edelson… - American journal of …, 1996 - atsjournals.org
We have previously demonstrated that induction of the stress response, by heat stress or
sodium arsenite, administered 18 h before initiation of sepsis in rats, significantly decreased …

Production of tumour necrosis factor α by primary cultured rat alveolar epithelial cells

DI McRitchie, N Isowa, JD Edelson, AM Xavier, L Cai… - Cytokine, 2000 - Elsevier
Tumour necrosis factor α(TNF-α) is one of the most important pro-inflammatory cytokines,
which plays an important role in host defense and acute inflammation related to tissue injury. …

Corticosteroids as adjunctive therapy in treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome

DK MacFadden, RH Hyland, T Inouye, JD Edelson… - The Lancet, 1987 - Elsevier
10 patients with the acquired immunodeficiency syndrome whose respiratory failure due to
Pneumocystis carinii pneumonia (PCP) was deteriorating rapidly had 7 days of intravenous …

Acute lung injury induced by phospholipase A2

JD Edelson, P Vadas, J Villar, JBM Mullen… - Am Rev Respir …, 1991 - atsjournals.org
On the basis of the observation that serum levels of phospholipase A2 (PLA2) are elevated
in pancreatitis and systemic sepsis, and the association of these conditions with the …

Vitamin D stimulates DNA synthesis in alveolar type-II cells

JD Edelson, S Chan, D Jassal, M Post… - Biochimica et Biophysica …, 1994 - Elsevier
Alveolar type-II cells are responsible for alveolar epithelial cell proliferation during growth
and development and in response to lung injury. Based on the observation of abnormal lung …

Autofluorescence of alveolar macrophages: problems and potential solutions

JD Edelson, DK MacFadden, M Klein, AS Rebuck - Medical hypotheses, 1985 - Elsevier
Despite recent advances in immunofluorescence technology, the study of alveolar macrophage
cell surface proteins is hampered by the presence of autofluorescence. We suggest …

Amiodarone pulmonary toxicity: functional and ultrastructural evaluation.

FL Liu, RD Cohen, E Downar, JW Butany, JD Edelson… - Thorax, 1986 - thorax.bmj.com
Pulmonary function, chest radiographic appearances, and the cellular composition of
bronchoalveolar lavage fluid were assessed in 13 patients who were receiving amiodarone …