… Contributors: David Lau and James Douketis were the principal coauthors of the executive
summary. All of the authors contributed substantially to the conception and design and to the …

Background Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-founded
fear of bleeding. Drug and food interactions are frequently cited as causes of …

This article discusses the perioperative management of antithrombotic therapy and is part of
the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th …

… The development of article recommendations was guided by the topic editor (RK),
whereas the development of the article narrative was overseen by the deputy editor (JD). …

Background It is uncertain whether bridging anticoagulation is necessary for patients with
atrial fibrillation who need an interruption in warfarin treatment for an elective operation or …

… JD Douketis—no relevant conflicts for present work. Consulting fees or honoraria from Janssen,
… Douketis contributed to the concept, analysis/interpretation of data, critical writing, and …

BACKGROUND: Obesity is a common health problem that requires a long-term care
approach. We systematically reviewed long-term (≥ 2 y) studies investigating dietary/lifestyle, …

Background: Clinicians should consider the clinical impact of anticoagulant-related
bleeding when deciding on the duration of anticoagulant therapy in patients with venous …

… All eligible studies were reviewed independently by 2 authors (JD and SB) to assess
suitability for inclusion, and all included studies were reviewed to assess agreement in outcome …

Background: Underutilization of anticoagulant prophylaxis may be due to lack of evidence
that prophylaxis prevents clinically important outcomes in hospitalized medical patients at risk …