Canadian atrial fibrillation anticoaguiation (CAFA) study

…, A Laupacis, M Gent, RS Roberts, JA Cairns… - Journal of the American …, 1991 - Elsevier
The Canadian Atrial Fibrillation Anticoagulation Study was a randomized double-blind
placebo-controlled trial to assess the potential of warfarin to reduce systemic thromboembolism …

Aspirin, sulfinpyrazone, or both in unstable angina: results of a Canadian multicenter trial

JA Cairns, M Gent, J Singer, KJ Finnie… - … England Journal of …, 1985 - Mass Medical Soc
We performed a randomized, double-blind, placebo-controlled trial in 555 patients with
unstable angina who were hospitalized in coronary care units. Patients received one of four …

Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT

JA Cairns, SJ Connolly, R Roberts, M Gent - The Lancet, 1997 - thelancet.com
… Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive
ventricular premature depolarisations: CAMIAT—In this article by JA Cairns and colleagues …

[HTML][HTML] Randomized trial of primary PCI with or without routine manual thrombectomy

SS Jolly, JA Cairns, S Yusuf, B Meeks… - … England Journal of …, 2015 - Mass Medical Soc
Background During primary percutaneous coronary intervention (PCI), manual thrombectomy
may reduce distal embolization and thus improve microvascular perfusion. Small trials …

The 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society comprehensive guidelines for the management of atrial fibrillation

…, M Aguilar, C Atzema, A Bell, JA Cairns… - Canadian Journal of …, 2020 - Elsevier
The Canadian Cardiovascular Society (CCS) atrial fibrillation (AF) guidelines program was
developed to aid clinicians in the management of these complex patients, as well as to …

[HTML][HTML] Complete revascularization with multivessel PCI for myocardial infarction

…, J Nakamya, SI Bangdiwala, JA Cairns - … England Journal of …, 2019 - Mass Medical Soc
Background In patients with ST-segment elevation myocardial infarction (STEMI), percutaneous
coronary intervention (PCI) of the culprit lesion reduces the risk of cardiovascular death …

Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control

AC Skanes, JS Healey, JA Cairns, P Dorian… - Canadian Journal of …, 2012 - Elsevier
The Canadian Cardiovascular Society (CCS) published the complete set of 2010 Atrial
Fibrillation (AF) Guidelines in the January, 2011 issue of the Canadian Journal of Cardiology. …

2014 focused update of the Canadian Cardiovascular Society Guidelines for the management of atrial fibrillation

A Verma, JA Cairns, LB Mitchell, L Macle… - Canadian Journal of …, 2014 - Elsevier
Atrial fibrillation (AF) is an extremely common clinical problem with an important population
morbidity and mortality burden. The management of AF is complex and fraught with many …

Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression.

JA Cairns, AF Walls - Journal of immunology (Baltimore, Md.: 1950), 1996 - journals.aai.org
Tryptase, a protease unique to the mast cell secretory granule, is released in substantial
quantities into the respiratory tract of patients with inflammatory disease of the airways. We have …

Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts.

JA Cairns, AF Walls - The Journal of clinical investigation, 1997 - Am Soc Clin Investig
Mast cell activation is a characteristic feature of chronic inflammation, a condition that may
lead to fibrosis as a result of increased collagen synthesis by fibroblasts. We have …