Introduction of tumor markers into routine clinical practice has been poorly controlled, with
few criteria or guidelines as to how such markers should be used. We propose a Tumor …

Rapid decreases in water temperature may result in a number of physiological, behavioural
and fitness consequences for fishes termed ‘cold shock’. Cold‐shock stress occurs when a …

Toxicology can no longer be used only as a science that reacts to problems but must be more
proactive in predicting potential human safety issues with new drug candidates. Success …

To assess the efficacy of surgical resection of brain metastases from extracranial primary
cancer, we randomly assigned patients with a single brain metastasis to either surgical removal …

Twelve hundred ninety-six patients with resected colon cancer that either was locally invasive
(Stage B 2 ) or had regional nodal involvement (Stage C) were randomly assigned to …

ContextCarcinoma of the esophagus traditionally has been treated by surgery or radiation
therapy (RT), but 5-year overall survival rates have been only 5% to 10%. We previously …

Background Surgical resection of adenocarcinoma of the stomach is curative in less than 40
percent of cases. We investigated the effect of surgery plus postoperative (adjuvant) …

Purpose: To determine the relationship, in patients with adenocarcinoma of the colon, between
survival and the number of lymph nodes analyzed from surgical specimens. Patients and …

… Macdonald JS: Carcinoembryonic antigen screening: Pros and cons. Semin Oncol 26:556-560,
1999 … Moertel CG, Fleming TR, Macdonald JS, et al: An evaluation of the carcinoembryonic …

Objective: To determine the effectiveness of two adjuvant therapy regimens in improving
surgical cure rates in stage III (Dukes stage C) colon cancer. Design: Randomized, concurrently …