Pharmacokinetics and tolerance of the phage endolysin-based candidate drug SAL200 after a single intravenous administration among healthy volunteers
SY Jun, IJ Jang, S Yoon, K Jang, KS Yu… - Antimicrobial agents …, 2017 - Am Soc Microbiol
This study was a phase 1, single-center, randomized, double-blind, placebo-controlled,
single-dosing, and dose-escalating study of intravenous SAL200. It is a new candidate drug for …
single-dosing, and dose-escalating study of intravenous SAL200. It is a new candidate drug for …
MRP2 haplotypes confer differential susceptibility to toxic liver injury
…, CY Chon, KH Han, SH Ahn, IJ Jang… - Pharmacogenetics …, 2007 - journals.lww.com
Objectives Multidrug resistance protein 2 (MRP2, ABCC2) plays an important role in the biliary
clearance of a wide variety of endogenous and exogenous toxic compounds. Therefore, …
clearance of a wide variety of endogenous and exogenous toxic compounds. Therefore, …
[HTML][HTML] Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway
Metformin is a first-line drug for treating type 2 diabetes. Although metformin is known to
phosphorylate AMP-activated protein kinase (AMPK), it is unclear how the glucose-lowering …
phosphorylate AMP-activated protein kinase (AMPK), it is unclear how the glucose-lowering …
[HTML][HTML] A database of 5305 healthy Korean individuals reveals genetic and clinical implications for an East Asian population
Despite substantial advances in disease genetics, studies to date have largely focused on
individuals of European descent. This limits further discoveries of novel functional genetic …
individuals of European descent. This limits further discoveries of novel functional genetic …
A variant 2677A allele of the MDR1 gene affects fexofenadine disposition
…, HR Jung, JY Cho, KS Yu, IJ Jang… - Clinical …, 2004 - Wiley Online Library
Background and Objectives There have been considerable disagreements regarding the
influence of MDR1 (ABCB1) polymorphisms on the disposition of P‐glycoprotein (P‐gp) …
influence of MDR1 (ABCB1) polymorphisms on the disposition of P‐glycoprotein (P‐gp) …
A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases
…, DS Kim, JH Yoon, Y Suh, IJ Jang… - Human molecular …, 2003 - academic.oup.com
Aberrant membrane transport caused by mutations in the cystic fibrosis transmembrane
conductance regulator (CFTR) gene is associated with a wide spectrum of respiratory and …
conductance regulator (CFTR) gene is associated with a wide spectrum of respiratory and …
[HTML][HTML] Colorectal cancer diagnostic model utilizing metagenomic and metabolomic data of stool microbial extracellular vesicles
…, WH Lee, D Ho Lee, S Kym, YS Park, JG Kim, IJ Jang… - Scientific reports, 2020 - nature.com
Colorectal cancer (CRC) is the most common type cancers in the world. CRC occurs
sporadically in the majority of cases, indicating the predominant cause of the disease are …
sporadically in the majority of cases, indicating the predominant cause of the disease are …
Night‐time gastric acid suppression by tegoprazan compared to vonoprazan or esomeprazole
…, SS Park, GS Song, KS Yu, IJ Jang… - British Journal of …, 2022 - Wiley Online Library
… Investigator for this paper is In-Jin Jang and that he had … , Kyung-Sang Yu, In-Jin Jang and
SeungHwan Lee performed … Kyung-Sang Yu, In-Jin Jang and SeungHwan Lee designed the …
SeungHwan Lee performed … Kyung-Sang Yu, In-Jin Jang and SeungHwan Lee designed the …
Apple juice greatly reduces systemic exposure to atenolol
H Jeon, IJ Jang, SH Lee, K Ohashi… - British journal of …, 2013 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Atenolol is an antihypertensive drug,
of which negligible amounts are metabolized. • Fruit juices may decrease the oral …
of which negligible amounts are metabolized. • Fruit juices may decrease the oral …
[HTML][HTML] Comprehensive metabolomic search for biomarkers to differentiate early stage hepatocellular carcinoma from cirrhosis
DJ Kim, EJ Cho, KS Yu, IJ Jang, JH Yoon, T Park… - Cancers, 2019 - mdpi.com
The established biomarker for hepatocellular carcinoma (HCC), serum α-fetoprotein (AFP),
has suboptimal performance in early disease stages. This study aimed to develop a …
has suboptimal performance in early disease stages. This study aimed to develop a …