Pharmacokinetics and tolerance of the phage endolysin-based candidate drug SAL200 after a single intravenous administration among healthy volunteers

SY Jun, IJ Jang, S Yoon, K Jang, KS Yu… - Antimicrobial agents …, 2017 - Am Soc Microbiol
This study was a phase 1, single-center, randomized, double-blind, placebo-controlled,
single-dosing, and dose-escalating study of intravenous SAL200. It is a new candidate drug for …

MRP2 haplotypes confer differential susceptibility to toxic liver injury

…, CY Chon, KH Han, SH Ahn, IJ Jang… - Pharmacogenetics …, 2007 - journals.lww.com
Objectives Multidrug resistance protein 2 (MRP2, ABCC2) plays an important role in the biliary
clearance of a wide variety of endogenous and exogenous toxic compounds. Therefore, …

[HTML][HTML] Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway

K Cho, JY Chung, SK Cho, HW Shin, IJ Jang… - Scientific reports, 2015 - nature.com
Metformin is a first-line drug for treating type 2 diabetes. Although metformin is known to
phosphorylate AMP-activated protein kinase (AMPK), it is unclear how the glucose-lowering …

[HTML][HTML] A database of 5305 healthy Korean individuals reveals genetic and clinical implications for an East Asian population

J Lee, J Lee, S Jeon, J Lee, I Jang, JO Yang… - … & Molecular Medicine, 2022 - nature.com
Despite substantial advances in disease genetics, studies to date have largely focused on
individuals of European descent. This limits further discoveries of novel functional genetic …

A variant 2677A allele of the MDR1 gene affects fexofenadine disposition

…, HR Jung, JY Cho, KS Yu, IJ Jang… - Clinical …, 2004 - Wiley Online Library
Background and Objectives There have been considerable disagreements regarding the
influence of MDR1 (ABCB1) polymorphisms on the disposition of P‐glycoprotein (P‐gp) …

A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases

…, DS Kim, JH Yoon, Y Suh, IJ Jang… - Human molecular …, 2003 - academic.oup.com
Aberrant membrane transport caused by mutations in the cystic fibrosis transmembrane
conductance regulator (CFTR) gene is associated with a wide spectrum of respiratory and …

[HTML][HTML] Colorectal cancer diagnostic model utilizing metagenomic and metabolomic data of stool microbial extracellular vesicles

…, WH Lee, D Ho Lee, S Kym, YS Park, JG Kim, IJ Jang… - Scientific reports, 2020 - nature.com
Colorectal cancer (CRC) is the most common type cancers in the world. CRC occurs
sporadically in the majority of cases, indicating the predominant cause of the disease are …

Night‐time gastric acid suppression by tegoprazan compared to vonoprazan or esomeprazole

…, SS Park, GS Song, KS Yu, IJ Jang… - British Journal of …, 2022 - Wiley Online Library
… Investigator for this paper is In-Jin Jang and that he had … , Kyung-Sang Yu, In-Jin Jang and
SeungHwan Lee performed … Kyung-Sang Yu, In-Jin Jang and SeungHwan Lee designed the …

Apple juice greatly reduces systemic exposure to atenolol

H Jeon, IJ Jang, SH Lee, K Ohashi… - British journal of …, 2013 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Atenolol is an antihypertensive drug,
of which negligible amounts are metabolized. • Fruit juices may decrease the oral …

[HTML][HTML] Comprehensive metabolomic search for biomarkers to differentiate early stage hepatocellular carcinoma from cirrhosis

DJ Kim, EJ Cho, KS Yu, IJ Jang, JH Yoon, T Park… - Cancers, 2019 - mdpi.com
The established biomarker for hepatocellular carcinoma (HCC), serum α-fetoprotein (AFP),
has suboptimal performance in early disease stages. This study aimed to develop a …