User profiles for Ian Pike

Ian Pike

Professor of Pediatrics, The University of British Columbia
Verified email at bcchr.ca
Cited by 5510

[HTML][HTML] Risky play and children's safety: Balancing priorities for optimal child development

M Brussoni, LL Olsen, I Pike, DA Sleet - International journal of …, 2012 - mdpi.com
Injury prevention plays a key role in keeping children safe, but emerging research suggests
that imposing too many restrictions on children’s outdoor risky play hinders their …

Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses

…, MP Jedrychowski, JC Rogers, K Kuhn, I Pike… - Analytical …, 2012 - ACS Publications
Quantitative mass spectrometry methods offer near-comprehensive proteome coverage;
however, these methods still suffer with regards to sample throughput. Multiplex quantitation via …

TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples

…, R Viner, AM Robitaille, AH Thompson, K Kuhn, I Pike… - Nature …, 2020 - nature.com
Isobaric labeling empowers proteome-wide expression measurements simultaneously
across multiple samples. Here an expanded set of 16 isobaric reagents based on an isobutyl-…

TMTpro-18plex: the expanded and complete set of TMTpro reagents for sample multiplexing

J Li, Z Cai, RD Bomgarden, I Pike, K Kuhn… - Journal of proteome …, 2021 - ACS Publications
The development of the TMTpro-16plex series expanded the breadth of commercial isobaric
tagging reagents by nearly 50% over classic TMT-11plex. In addition to the described …

[HTML][HTML] Plasma proteins predict conversion to dementia from prodromal disease

…, M Lupton, K Lunnon, A Keohane, M Ward, I Pike… - Alzheimer's & …, 2014 - Elsevier
Background The study aimed to validate previously discovered plasma biomarkers associated
with AD, using a design based on imaging measures as surrogate for disease severity …

Failure of implantation in human in vitro fertilization and embryo transfer patients: the effects of altered progesterone/estrogen ratios in humans and mice

…, C O'Neill, MJ Sinosich, RN Porter, IL Pike… - Fertility and sterility, 1986 - Elsevier
Daily blood samples were taken for progesterone (P) and estradiol (E 2 ) measurements
from women who showed a platelet response consistent with the presence of viable embryos …

TMTpro: design, synthesis, and initial evaluation of a proline-based isobaric 16-plex tandem mass tag reagent set

…, V Farztdinov, S Jung, K Kuhn, I Pike - Analytical …, 2019 - ACS Publications
The design and synthesis of a proline-based reporter isobaric Tandem Mass Tag structure (TMTpro)
is presented. An analysis is made of the performance of the new TMTpro tags in …

Efficiency of feed utilization in Atlantic salmon (Salmo salar L.) fed diets with increasing substitution of fish meal with vegetable proteins

J Opstvedt, A Aksnes, B Hope, IH Pike - Aquaculture, 2003 - Elsevier
Atlantic salmon smolts were fed for 15-week diets where 28% and 55% of the fish meal,
respectively, were replaced by a mixture of full-fat soybean meal and maize gluten meal in …

[HTML][HTML] The impact of COVID-19 on high school student-athlete experiences with physical activity, mental health, and social connection

…, KL Belton, S Karmali, S Pawer, G Hadly, I Pike… - International Journal of …, 2021 - mdpi.com
COVID-19 restrictions led to reduced levels of physical activity, increased screen usage, and
declines in mental health in youth; however, in-depth understandings of the experiences of …

[HTML][HTML] Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

…, S Martinozzi-Teissier, A Natsch, D Petersohn, I Pike… - Toxicology in Vitro, 2015 - Elsevier
The need for non-animal data to assess skin sensitisation properties of substances, especially
cosmetics ingredients, has spawned the development of many in vitro methods. As it is …