We have generated a novel transgenic mouse model on a C57BL/6J genetic background
that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated …

New technologies to generate, store and retrieve medical and research data are inducing a
rapid change in clinical and translational research and health care. Systems medicine is the …

To study Alzheimer’s disease (AD), a variety of mouse models has been generated through
the overexpression of the amyloid precursor protein and/or the presenilins harboring one or …

Microglial cells aggregate around amyloid plaques in Alzheimer's disease, but, despite their
therapeutic potential, various aspects of their reactive kinetics and role in plaque …

Cilia play an essential role in protecting the respiratory tract by providing the force necessary
for mucociliary clearance. Although the major structural components of human cilia have …

In Alzheimer's disease, microglia cluster around β-amyloid deposits, suggesting that these
cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed …

Liver resection causes marked perfusion alterations in the liver remnant both on the organ
scale (vascular anatomy) and on the microscale (sinusoidal blood flow on tissue level). These …

Alzheimer's disease presents morphologically with senile plaques, primarily made of
extracellular amyloid-β (Aβ) deposits, and neurofibrillary lesions, which consist of intracellular …

The mammalian auditory sensory organ, the organ of Corti, consists of sensory hair cells with
uniformly oriented stereocilia on the apical surfaces and has a distinct planar cell polarity (…

METHODS About 46% of Minnesota was considered in this study (Fig. 1). The region is
primarily coniferous and deciduous forest, but the southern and western portions also contain …