An international consensus report in 2019 recommended a classification system for limbic-predominant
age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The …

Objectives Amyloid‐beta (Aβ) and tau pathologies are commonly observed among clinically
normal older individuals at postmortem and can now be detected with in vivo neuroimaging. …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

Tau and amyloid beta (Aβ) proteins accumulate along neuronal circuits in Alzheimer’s disease.
Unraveling the genetic background for the regional vulnerability of these proteinopathies …

Importance In the absence of disease-modifying therapies for Alzheimer disease, there is a
critical need to identify modifiable risk factors that may delay the progression of Alzheimer …

Background Mitochondrial dysfunction is a feature of neurodegenerative diseases, including
Alzheimer’s disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and …

Background Transactive response DNA-binding protein of 43 kDa (TDP-43) proteinopathy
in older adults frequently coexists with Alzheimer's disease pathology and hippocampal …

This study explores the applicability of organic dye-sensitized TiO 2 particles in the production
of molecular hydrogen and remediation of environmental pollutants (4-chlorophenol and …

Approximately 30% of older adults exhibit the neuropathological features of Alzheimer’s
disease without signs of cognitive impairment. Yet, little is known about the genetic factors that …

Importance An increased tau positron emission tomography (PET) signal in the medial
temporal lobe (MTL) has been observed in older individuals in the absence of amyloid-β (Aβ) …