User profiles for Hui Zheng

Hui Zheng

ShanghaiTech University
Verified email at shanghaitech.edu.cn
Cited by 2993

SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

…, G Yu, W Xia, Z Du, C Huang, J Ma, H Zheng… - Nature …, 2019 - nature.com
The oocyte epigenome plays critical roles in mammalian gametogenesis and embryogenesis.
Yet, how it is established remains elusive. Here, we report that histone-lysine N-…

[HTML][HTML] Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice

…, LE Goldstein, RD Moir, JT Lim, K Beyreuther, H Zheng… - Neuron, 2001 - cell.com
Inhibition of neocortical β-amyloid (Aβ) accumulation may be essential in an effective therapeutic
intervention for Alzheimer's disease (AD). Cu and Zn are enriched in Aβ deposits in AD, …

Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study

…, PA Liu, XG Jiang, YY Jiang, JP Wang, H Zheng… - Diabetes …, 1997 - Am Diabetes Assoc
OBJECTIVE Individuals with impaired glucose tolerance (IGT) have a high risk of developing
NIDDM. The purpose of this study was to determine whether diet and exercise interventions …

[PDF][PDF] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models

…, VM Philip, GR Howell, H Martini-Stoica, H Zheng… - Cell reports, 2020 - cell.com
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …

β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

H Zheng, M Jiang, ME Trumbauer, DJS Sirinathsinghji… - Cell, 1995 - cell.com
In several pedigrees of early onset familial Alzheimer’s disease (FAD), point mutations in the
(I-amyloid precursor protein (APP) gene are genetically linked to the disease. This finding …

Translating the A1C assay into estimated average glucose values

DM Nathan, J Kuenen, R Borg, H Zheng… - Diabetes …, 2008 - Am Diabetes Assoc
OBJECTIVE—The A1C assay, expressed as the percent of hemoglobin that is glycated,
measures chronic glycemia and is widely used to judge the adequacy of diabetes treatment and …

Epidemiological serosurvey of hepatitis B in China—declining HBV prevalence due to hepatitis B vaccination

…, Y Zhang, J Liu, X Gong, Y Chen, F Wang, H Zheng… - vaccine, 2009 - Elsevier
OBJECTIVE: To determine the prevalence of hepatitis B surface antigen (HBsAg), hepatitis
B surface antibody (anti-HBs), and hepatitis B core anti-body (anti-HBc) in a representative …

Immunoregulation in diabetic wound repair with a photoenhanced glycyrrhizic acid hydrogel scaffold

Y Qian, Y Zheng, J Jin, X Wu, K Xu, M Dai… - Advanced …, 2022 - Wiley Online Library
M1 macrophage accumulation and excessive inflammation are commonly encountered
issues in diabetic wounds and can fail in the healing process. Hence, hydrogel dressings with …

[HTML][HTML] MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response

F Hou, L Sun, H Zheng, B Skaug, QX Jiang, ZJ Chen - Cell, 2011 - cell.com
In response to viral infection, RIG-I-like RNA helicases bind to viral RNA and activate the
mitochondrial protein MAVS, which in turn activates the transcription factors IRF3 and NF-κB to …

[HTML][HTML] Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels

…, K Stephan, S Bova, H Chen, H Zheng… - Cell, 2000 - cell.com
Voltage-gated L-type Ca 2+ channels (LTCCs) containing a pore-forming α1D subunit (D-LTCCs)
are expressed in neurons and neuroendocrine cells. Their relative contribution to total …