User profiles for Hugh J. McMillan

Hugh McMillan

Professor, University of Ottawa
Verified email at cheo.on.ca
Cited by 4131

[HTML][HTML] Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial

…, K Saito, JR Mendell, L Servais, HJ McMillan… - Nature medicine, 2022 - nature.com
SPR1NT ( NCT03505099 ) was a Phase III, multicenter, single-arm study to investigate the
efficacy and safety of onasemnogene abeparvovec for presymptomatic children with biallelic …

[HTML][HTML] Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial

…, K Saito, JR Mendell, L Servais, HJ McMillan… - Nature medicine, 2022 - nature.com
Most children with biallelic SMN1 deletions and three SMN2 copies develop spinal muscular
atrophy (SMA) type 2. SPR1NT ( NCT03505099 ), a Phase III, multicenter, single-arm trial, …

Myostatin inhibitor ACE‐031 treatment of ambulatory boys with Duchenne muscular dystrophy: results of a randomized, placebo‐controlled clinical trial

C Campbell, HJ McMillan, JK Mah… - Muscle & …, 2017 - Wiley Online Library
Introduction: ACE‐031 is a fusion protein of activin receptor type IIB and IgG1‐Fc, which
binds myostatin and related ligands. It aims to disrupt the inhibitory effect on muscle …

[HTML][HTML] Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis

…, T Sejersen, HJ McMillan, J Kirschner… - European journal of …, 2020 - Springer
Several studies indicate that prognosis for survival in Duchenne muscular dystrophy (DMD)
has improved in recent decades. However, published evidence is inconclusive and some …

Effect of different corticosteroid dosing regimens on clinical outcomes in boys with Duchenne muscular dystrophy: a randomized clinical trial

…, G Vita, GL Vita, JF Howard, I Hughes, HJ McMillan… - Jama, 2022 - jamanetwork.com
Importance Corticosteroids improve strength and function in boys with Duchenne muscular
dystrophy. However, there is uncertainty regarding the optimum regimen and dosage. …

Medical students' perception of lesbian, gay, bisexual, and transgender (LGBT) discrimination in their learning environment and their self-reported comfort level for …

…, P MacPherson, M Sampson, HJ McMillan - Medical education …, 2017 - Taylor & Francis
Background: Historically, medical students who are lesbian, gay, bisexual or transgendered
(LGBT) report higher rates of social stress, depression, and anxiety, while LGBT patients …

Emergence of the primary pediatric stroke center: impact of the thrombolysis in pediatric stroke trial

…, S Sultan, DD Cummings, EF Grabowski, HJ McMillan… - Stroke, 2014 - Am Heart Assoc
Background and Purpose— In adult stroke, the advent of thrombolytic therapy led to the
development of primary stroke centers capable to diagnose and treat patients with acute stroke …

Efficacy and safety of vamorolone vs placebo and prednisone among boys with Duchenne muscular dystrophy: a randomized clinical trial

…, M Tulinius, R Webster, HJ McMillan… - JAMA …, 2022 - jamanetwork.com
Importance Corticosteroidal anti-inflammatory drugs are widely prescribed but long-term
use shows adverse effects that detract from patient quality of life. Objective To determine if …

Pan-viral serology implicates enteroviruses in acute flaccid myelitis

…, KS Krishnamoorthy, T Chitnis, JZ Ding, HJ McMillan… - Nature medicine, 2019 - nature.com
Since 2012, the United States of America has experienced a biennial spike in pediatric
acute flaccid myelitis (AFM) 1 , 2 , 3 , 4 , 5 – 6 . Epidemiologic evidence suggests non-polio …

Abnormal fatty acid metabolism is a core component of spinal muscular atrophy

…, J Warman Chardon, HJ McMillan… - Annals of clinical …, 2019 - Wiley Online Library
Objective Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder leading to
paralysis and subsequent death in young children. Initially considered a motor neuron …