When little or no data directly comparing two treatments are available, investigators often
rely on indirect comparisons from studies testing the treatments against a control or placebo. …

Background Low-carbohydrate diets have become increasingly popular for weight loss.
However, evidence from individual trials about benefits and risks of these diets to achieve weight …

Objective To quantify the overall effects of bariatric surgery compared with non-surgical
treatment for obesity. Design Systematic review and meta-analysis based on a random effects …

Context In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in
patients with lower respiratory tract infections (LRTIs). Objective To examine whether a PCT …

PURPOSE: Observational studies have shown an inconsistent association between n-3
polyunsaturated fatty acids and the risk of coronary heart disease. We investigated the effects of …

Background Acute respiratory infections (ARIs) comprise a large and heterogeneous group
of infections including bacterial, viral and other aetiologies. In recent years, procalcitonin ‐ …

ContextRandomized clinical trials (RCTs) that stop earlier than planned because of apparent
benefit often receive great attention and affect clinical practice. Their prevalence, the …

Objective To investigate the association between treatment induced change in high density
lipoprotein cholesterol and total death, coronary heart disease death, and coronary heart …

Background Air pollution is hypothesized to be a risk factor for diabetes. Epidemiological
evidence is inconsistent and has not been systematically evaluated. Objectives We …

Background Acute respiratory tract infections are the most common reason for antibiotic
therapy in primary care despite their mainly viral etiology. A laboratory test measuring …