The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …

RAF family kinases were among the first oncoproteins to be described more than 30 years
ago. They primarily act as signalling relays downstream of RAS, and their close ties to cancer …

Expression of the genes that mediate the first steps in steroidogenesis, the steroidogenic
acute regulatory protein (STARD1), the cholesterol side-chain cleavage enzyme, cytochrome …

… of H-RAS 11 , we performed combinatorial library selection for monobodies that interact with
H… We identified NS1, which binds H-RAS with low-nanomolar affinity and K-RAS with slightly …

Idiopathic hypogonadotropic hypogonadism (IHH) is a condition characterized by failure to
undergo puberty in the setting of low sex steroids and low gonadotropins. IHH is due to …

… LaVoie, Assistant Professor, also was recognized for her excellence in teaching with the
prestigious String of Pearls Award from the first-year medical students. Her research interests …

RAF kinases have a prominent role in cancer. Their mode of activation is complex but
critically requires dimerization of their kinase domains. Unexpectedly, several ATP-competitive …

Gene expression variation between species is a major contributor to phenotypic diversity, yet
the underlying flexibility of transcriptional regulatory networks remains largely unexplored. …

… We next measured BRAF levels at two time points: at 1 h, at which time no BRAF destruction
was achieved; and at 24 h, at which time maximal BRAF destruction was achieved. At 1 h, …

Reported RAF kinase domain structures adopt a side-to-side dimer configuration reflective
of an 'on' state that underpins an allosteric mechanism of regulation. Atomic details of the …