Wnt proteins are a family of secreted proteins that regulate many aspects of cell growth,
differentiation, function, and death. Considerable progress has been made in our understanding …

Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …

… The localisation of 52 changed over time, from mitochondrial (<4 h incubation) to lysosomal
at the 24-h time point, potentially indicating the trafficking of 52 out of the cells. Compound …

… Cells were plated onto coverslips 24 h before 24-h treatments, as indicated. After treatments,
the medium was removed, coverslips rinsed once in PBS at 37 C and fixed and stained as …

Background Cancer survival is a key measure of the effectiveness of health-care systems.
Persistent regional and international differences in survival represent many avoidable deaths. …

Background Population-based cancer survival estimates provide valuable insights into the
effectiveness of cancer services and can reflect the prospects of cure. As part of the second …

If replication forks are perturbed, a multifaceted response including several DNA repair and
cell cycle checkpoint pathways is activated to ensure faithful DNA replication. Here, we show …

… Telomerase-immortalized NHU were incubated for 8 h with retroviral supernatant
containing 8 μg/mL polybrene and selected with hygromycin 48 h after transduction. FGF1 cell …

… We plated 1.5 ×10 6 S8SN.11 cells 4 h prior to a 24-hour treatment with thymidine (10 mM)
or camptothecin (100 nM; in 0.2% dimethyl sulfoxide final concentration). For I-SceI-induced …

The effect of cigarette smoking on recurrence (defined in this study as the need for repeat
surgery) in patients who had previously required surgery for Crohn's disease was assessed in …