The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) is a randomized,
double-blind, placebo-controlled trial designed to test the hypothesis that treatment with …

OBJECTIVES: To compare the risk of mortality of nonagenarian siblings with that of sporadic
nonagenarians (not selected on having a nonagenarian sibling) and to compare the …

Background Handgrip strength (HGS) is used to identify individuals with low muscle strength
(dynapenia). The influence of the number of attempts on maximal HGS is not yet known and …

Circulatory diseases account for approximately 30% of the 55 million deaths that occur in the
world each year, and represent the major cause of mortality in industrialized nations. In the …

OBJECTIVES: To explore measures of metabolic syndrome and glucose metabolism in families
with exceptional longevity. DESIGN: Case–control study. SETTING: A university hospital …

Background: A consensus on the diagnostic criteria for sarcopenia, a common syndrome in
the elderly, has not been reached yet. Prevalence rates vary between studies due to the use …

Objectives This study aimed to explore the concordance between definitions of sarcopenia
and frailty in a clinically relevant population of geriatric outpatients. Design Data were …

Background The hypothalamo-pituitary-thyroid axis has been widely implicated in modulating
the aging process. Life extension effects associated with low thyroid hormone levels have …

Background: screening for frailty might help to prevent adverse outcomes in hospitalised
older adults. Objective: to identify the most predictive and efficient screening tool for frailty. …

Purpose To assess the prevalence and number of cortical microinfarcts in patients with
Alzheimer disease (AD) by using a 7-T magnetic resonance (MR) imaging system, to assess the …