Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - academic.oup.com
The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …
New insights into the regulation of HDL metabolism and reverse cholesterol transport
GF Lewis, DJ Rader - Circulation research, 2005 - Am Heart Assoc
The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of
atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating HDL …
atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating HDL …
2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult …
… Jacques Genest MD1, Ruth McPherson MD PhD2, Jiri Frohlich MD3, Todd Anderson MD4,
Norm Campbell MD4, André Carpentier MD5, Patrick Couture MD6, Robert Dufour MD7, George …
Norm Campbell MD4, André Carpentier MD5, Patrick Couture MD6, Robert Dufour MD7, George …
Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus …
Recent advances in human genetics, together with a large body of epidemiologic, preclinical,
and clinical trial results, provide strong support for a causal association between …
and clinical trial results, provide strong support for a causal association between …
Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans.
GF Lewis, KD Uffelman, LW Szeto… - The Journal of …, 1995 - Am Soc Clin Investig
Changes in VLDL triglyceride and VLDL apo B production were determined semiquantitatively
in healthy young men by examining the effect of altering plasma insulin and/or FFA levels …
in healthy young men by examining the effect of altering plasma insulin and/or FFA levels …
Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals
GF Lewis, KD Uffelman, LW Szeto, G Steiner - Diabetes, 1993 - Am Diabetes Assoc
The effects of short-term hyperinsulinemia on the production of both VLDL triglyceride and
VLDL apoB were determined semiquantitatively before and during a 6-h euglycemic …
VLDL apoB were determined semiquantitatively before and during a 6-h euglycemic …
[HTML][HTML] Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance: evidence for enhanced lipoprotein assembly, reduced intracellular …
…, B Chen, D Rudy, A Aiton, GF Lewis… - Journal of Biological …, 2000 - ASBMB
A novel animal model of insulin resistance, the fructose-fed Syrian golden hamster, was
employed to investigate the mechanisms mediating the overproduction of very low density …
employed to investigate the mechanisms mediating the overproduction of very low density …
Mechanisms of the free fatty acid-induced increase in hepatic glucose production
TKT Lam, A Carpentier, GF Lewis… - American Journal …, 2003 - journals.physiology.org
The associations between obesity, insulin resistance, and type 2 diabetes mellitus are well
documented. Free fatty acids (FFA), which are often elevated in obesity, have been …
documented. Free fatty acids (FFA), which are often elevated in obesity, have been …
Acute effects of insulin in the control of VLDL production in humans. Implications for the insulin-resistant state.
GF Lewis, G Steiner - Diabetes care, 1996 - europepmc.org
The role of hyperinsulinemia in the pathogenesis of triglyceride (TG) and VLDL over-production
in insulin-resistant states remains controversial. While studies in humans and animals …
in insulin-resistant states remains controversial. While studies in humans and animals …
Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity
S Rashid, T Watanabe, T Sakaue, GF Lewis - Clinical biochemistry, 2003 - Elsevier
Hypertriglyceridemia, low plasma concentrations of high density lipoproteins (HDL) and
qualitative changes in low density lipoproteins (LDL) comprise the typical dyslipidemia of insulin …
qualitative changes in low density lipoproteins (LDL) comprise the typical dyslipidemia of insulin …