Monoclonal antibody therapeutics have been approved for over 30 targets and diseases,
most commonly cancer. Antibodies have become the new backbone of the pharmaceutical …

Oral mucositis (OM) is a debilitating early adverse effect of allogeneic hematopoietic stem
cell transplantation (HSCT). The intensity of the conditioning regimen correlates with the …

The mission of the American Diabetes Association is “to prevent and cure diabetes and to
improve the lives of all people affected by diabetes.” Increasingly, scientific and medical …

Recent studies suggest that the population of malignant cells found in human acute
myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs). LSCs …

Background and Methods Allogeneic bone marrow transplantation is curative in a substantial
number of patients with hematologic cancers, marrow-failure disorders, immunodeficiency …

Artificial fertilization of lakes ultimately leads to reduction in submerged macrophyte productivity.
This has usually been attributed to shading by increasing populations of phytoplankton. …

The vascular endothelium was once thought to function primarily in nutrient and oxygen
delivery, but recent evidence suggests that it may play a broader role in tissue homeostasis. To …

Trastuzumab (Herceptin ® ) is currently used as a treatment for patients whose breast
tumors overexpress HER2/ErbB2. Trastuzumab-DM1 (T-DM1, trastuzumab emtansine) is …

Fifty-seven patients with refractory acute leukemia were treated with high-dose cytosine
arabinoside to establish the maximum tolerated dose and duration and to determine the …

Introduction The human epidermal growth factor receptor 2 (HER2)-targeted therapies
trastuzumab (T) and lapatinib (L) show high efficacy in patients with HER2-positive breast cancer, …