… Correspondence to: GH Guyatt, CLARITY Research Group, Department of Clinical
Epidemiology and Biostatistics, Room 2C12, 1200 Main Street, West Hamilton, ON, Canada …

Objective To develop an evidence‐based guideline for the comprehensive management of
osteoarthritis ( OA ) as a collaboration between the American College of Rheumatology ( …

of Findings (SoF) tables present, for each of the seven (or fewer) most important outcomes,
the following: the number of studies and number of participants; the confidence in effect …

The most common reason for rating up the quality of evidence is a large effect. GRADE
suggests considering rating up quality of evidence one level when methodologically rigorous …

This article is the first of a series providing guidance for use of the Grading of Recommendations
Assessment, Development, and Evaluation (GRADE) system of rating quality of …

This article deals with inconsistency of relative (rather than absolute) treatment effects in
binary/dichotomous outcomes. A body of evidence is not rated up in quality if studies yield …

… The following members contributed to this article: Gordon Guyatt (Chair), MD, MSc; Eric Bass,
MD, MPH; Patrick Brill-Edwards,MD; George Browman, MD, MSc; Deborah Cook, MD, MSc…

Direct evidence comes from research that directly compares the interventions in which we
are interested when applied to the populations in which we are interested and measures …

GRADE suggests that examination of 95% confidence intervals (CIs) provides the optimal
primary approach to decisions regarding imprecision. For practice guidelines, rating down the …

CLINICAL SCENARIO You are back where we put you in the previous article 1 on diagnostic
tests in this series on how to use the medical literature: in the library studying an article that …