Background: Clinical trials are commonly done without blinded outcome assessors despite
the risk of bias. We wanted to evaluate the effect of nonblinded outcome assessment on …

Objective To evaluate the impact of non-blinded outcome assessment on estimated treatment
effects in randomised clinical trials with binary outcomes. Design Systematic review of …

Background: Blinding patients in clinical trials is a key methodological procedure, but the
expected degree of bias due to nonblinded patients on estimated treatment effects is unknown. …

Background: We wanted to evaluate the impact of nonblinded outcome assessors on
estimated treatment effects in time-to-event trials. Methods: Systematic review of randomized …

Background: Recurrent Clostridium difficile infection (CDI) is a significant problem due to its
increased incidence and severity. Failure rates for standard antibiotic therapies are high. In …

Background: Heterozygous familial hypercholesterolemia (FH) is a common genetic disorder
leading to premature cardiovascular disease and death as a result of lifelong high plasma …

Background: FMT has been proven to be a safe and highly effective therapeutic option for
CDI. Delivery, however, could be via the UGI or LGI routes, and it is unclear as to which route …

Background : Low-density lipoprotein cholesterol (LDL-C) is causally associated with a high
risk of coronary artery disease. Whether this also holds for a spectrum of peripheral vascular …

Context Individuals with familial hypercholesterolemia (FH) have a high risk of coronary
artery disease, but their risk of peripheral arterial disease (PAD) and chronic kidney disease (…

OBJECTIVE To evaluate whether high glucose levels in the normoglycemic range and
higher have a causal genetic effect on risk of retinopathy, neuropathy, nephropathy, chronic …