We randomly assigned 208 patients who underwent brain biopsy for presumptive herpes
simplex encephalitis to receive either vidarabine (15 mg per kilogram of body weight per day) …

Background An effective prophylactic vaccine would help control the spread of genital herpes.
Methods We conducted two double-blind, randomized trials of a herpes simplex virus type …

Background Cervical intraepithelial neoplasia grade 2 or greater (CIN2+) is the surrogate
endpoint used in licensure trials of human papillomavirus (HPV) vaccines. Vaccine efficacy …

Background The sialic acid analogue zanamivir (GG167) is a selective inhibitor of influenza
A and B virus neuraminidases. These viral enzymes are essential for the release of virus …

Background We evaluated the efficacy of the human papillomavirus HPV-16/18 AS04-adjuvanted
vaccine against non-vaccine oncogenic HPV types in the end-of-study analysis after 4 …

Our objective was to evaluate the benefit of early treatment of influenza illness using oral
oseltamivir. This open-label, multicentre international study investigated the relationship …

A survey of drug‐related admissions of patients aged 50 years and older was conducted at
the Health Sciences Centre, Winnipeg to determine the interrelationship of risk factors, and …

Amantadine is a drug with diverse uses ranging from prevention of influenza A illness to the
treatment of patients with Parkinson’s disease. It is available only in oral formulations from …

Background The control arm of PATRICIA (PApillomaTRIal against Cancer In young Adults,
NCT00122681) was used to investigate the risk of progression from cervical HPV infection to …

Oseltamivir phosphate is a prodrug of oseltamivir carboxylate, a highly specific inhibitor of
influenza virus neuraminidases. Given that oseltamivir carboxylate binds to highly conserved, …