User profiles for Ferrante S. Gragasin

Ferrante S. Gragasin

Assistant Clinical Professor, Dept. of Anesthesiology and Pain Medicine, University of …
Verified email at ualberta.ca
Cited by 1082

Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11, 12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle …

SL Archer, FS Gragasin, X Wu, S Wang, S McMurtry… - Circulation, 2003 - Am Heart Assoc
Background— Left internal mammary arteries (LIMAs) synthesize endothelium-derived
hyperpolarizing factor (EDHF), a short-lived K + channel activator that persists after inhibition of …

Prenatal hypoxia causes long-term alterations in vascular endothelin-1 function in aged male, but not female, offspring

SL Bourque, FS Gragasin, AL Quon, Y Mansour… - …, 2013 - Am Heart Assoc
Prenatal hypoxia can alter the growth trajectory of the fetus and cause lasting health complications
including vascular dysfunction. We hypothesized that offspring that were intrauterine …

Estrogen reduces angiotensin II–induced nitric oxide synthase and NAD (P) H oxidase expression in endothelial cells

FS Gragasin, Y Xu, IA Arenas, N Kainth… - … , and vascular biology, 2003 - Am Heart Assoc
Objective— Angiotensin II (AII) has been shown to increase endothelial NAD(P)H oxidase
activity, which is a source of superoxide anion that in turn may induce the formation of …

Perinatal resveratrol supplementation to spontaneously hypertensive rat dams mitigates the development of hypertension in adult offspring

AS Care, MM Sung, S Panahi, FS Gragasin… - …, 2016 - Am Heart Assoc
This study was undertaken to determine whether perinatal maternal resveratrol (Resv)—a
phytoalexin known to confer cardiovascular protection—could prevent the development of …

The neurovascular mechanism of clitoral erection: nitric oxide and cGMP‐stimulated activation of BKCa channels

FS Gragasin, ED Michelakis, A Hogan… - The FASEB …, 2004 - Wiley Online Library
Female sexual function is under‐studied, and mechanisms of clitoral engorgement‐relaxation
are incompletely understood. Penile erection results from nitric oxide (NO) ‐induced cyclic …

Aetiology and management of male erectile dysfunction and female sexual dysfunction in patients with cardiovascular disease

SL Archer, FS Gragasin, L Webster, D Bochinski… - Drugs & aging, 2005 - Springer
The historical basis for understanding erectile function as a neurovascular phenomenon
and the advance from fanciful to effective treatment of erectile dysfunction (ED) are reviewed, …

[HTML][HTML] Modest and severe maternal iron deficiency in pregnancy are associated with fetal anaemia and organ-specific hypoxia in rats

…, Y Mansour, SJ Cherak, S Panahi, FS Gragasin… - Scientific reports, 2017 - nature.com
Prenatal iron-deficiency (ID) is known to alter fetal developmental trajectories, which
predisposes the offspring to chronic disease in later life, although the underlying mechanisms …

Prenatal iron deficiency causes sex‐dependent mitochondrial dysfunction and oxidative stress in fetal rat kidneys and liver

…, RMN Noble, S Panahi, FS Gragasin… - The FASEB …, 2018 - Wiley Online Library
Prenatal iron deficiency alters fetal developmental trajectories, which results in persistent
changes in organ function. Here, we studied the effects of prenatal iron deficiency on fetal …

Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress

…, CD Holody, S Panahi, FS Gragasin… - Cardiovascular …, 2020 - academic.oup.com
Aims Perinatal iron deficiency (ID) alters developmental trajectories of offspring, predisposing
them to cardiovascular dysfunction in later life. The mechanisms underlying this long-term …

The effects of propofol on vascular function in mesenteric arteries of the aging rat

FS Gragasin, ST Davidge - American Journal of Physiology …, 2009 - journals.physiology.org
Hypotension following administration of propofol, an anesthetic agent, is strongly predicted
by advanced age and is partly due to direct vasodilation. We hypothesized that propofol …