Estrogen receptor β (ERβ) is a novel steroid receptor that is expressed in rat prostate and
ovary. We have cloned the mouse homolog of ERβ and mapped the gene, designated Estrb, to …

A large proportion of androgens in men (40%), and the majority of estrogens in women (75%
before menopause and close to 100% after menopause), are synthesized in peripheral …

The present data show a dramatic decline in the circulating levels of dehydroepiandrosterone
(DHEA), DHEA-sulfate (DHEA-S), androst-5-ene-3β,17β-diol (5-diol), 5-diol-sulfate, 5-diol-…

Background The association between aging-related testosterone deficiency and late-onset
hypogonadism in men remains a controversial concept. We sought evidence-based criteria …

It is difficult to identify genes that predispose to prostate cancer due to late age at diagnosis,
presence of phenocopies within high-risk pedigrees and genetic complexity. A genome-…

Context: The diagnosis of late-onset hypogonadism (LOH) in older men with age-related
declines in testosterone (T) is currently not well characterized. Objective: Our objective was to …

Serum androgens as well as their precursors and metabolites decrease from the age of 30–40
yr in women, thus suggesting that a more physiological hormone replacement therapy at …

The estrogen receptors (ERs) α and β possess a constitutive N-terminal activation function (AF-1)
whose activity can be modulated by kinase signaling pathways. We demonstrate here …

17β-Hydroxysteroid dehydrogenase (17β-HSD) controls the last step in the formation of all
androgens and all estrogens. This crucial role of 17β-HSD is performed by at least five 17β-…

OBJECTIVE To investigate the potential relationship between the cluster of metabolic
abnormalities found in visceral obesity and the small dense LDL phenotype. RESEARCH DESIGN …