Recognition of injured mitochondria for degradation by macroautophagy is essential for
cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) have been associated with familial
and sporadic cases of Parkinson disease. Mutant LRRK2 causes in vitro and in vivo neurite …

Mitochondrial Ca 2+ overload is a critical, preceding event in neuronal damage
encountered during neurodegenerative and ischemic insults. We found that loss of PTEN-induced …

The leucine rich repeat kinase 2 (LRRK2/dardarin) is implicated in autosomal dominant familial
and sporadic Parkinson's disease (PD); mutations in LRRK2 account for up to 40% of PD …

Mitochondrial quality control is mediated by the PTEN-induced kinase 1 (PINK1), a
cytoprotective protein that is dysregulated in inflammatory lung injury and neurodegenerative …

Significance: Disruptions in mitochondrial homeostasis are implicated in human diseases
across the lifespan. Recessive mutations in PINK1, which encodes the mitochondrially …

While PTEN-induced kinase 1 (PINK1) is well characterized for its role in mitochondrial
homeostasis, much less is known concerning its ability to prevent synaptodendritic degeneration. …

Mutations in leucine-rich repeat kinase 2 (LRRK2), which are associated with autosomal
dominant Parkinson's disease, elicit progressive dendrite degeneration in neurons. We …

… Doreen Matsui, Charisse Kwan, Erin Steer and Michael J. Rieder … Erin Steer prepared survey
packages and was involved in data collection. All authors gave approval of the final version …

BACKGROUND: Despite the important role of drug therapy in children, there is often a lack
of readily available information regarding the indications and dosing regimens for …