Background The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium
falciparum and has partial protective efficacy against clinical and severe malaria disease in …

Deep sequencing technologies have the potential to transform the study of highly variable
viral pathogens by providing a rapid and cost-effective approach to sensitively characterize …

The 2013–2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little
is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause …

Background: The choice to give birth at home with a regulated midwife in attendance became
available to expectant women in British Columbia in 1998. The purpose of this study was …

The potential application of phage therapy for the control of bacterial biofilms has received
increasing attention as resistance to conventional antibiotic agents continues to increase. The …

Objectives Bacteriophages are bacteria-specific viruses that infect and, in the case of obligately
lytic phages, destroy their host bacteria. Phage therapy has been used therapeutically to …

Background Extensive genetic diversity in viral populations within infected hosts and the
divergence of variants from existing reference genomes impede the analysis of deep viral …

Diverse soil-resident bacteria can contribute to plant growth and health, but the molecular
mechanisms enabling them to effectively colonize their plant hosts remain poorly understood. …

Known giant virus diversity is currently skewed towards viruses isolated from aquatic
environments and cultivated in the laboratory. Here, we employ cultivation-independent …

Viruses diversify over time within hosts, often undercutting the effectiveness of host defenses
and therapeutic interventions. To design successful vaccines and therapeutics, it is critical …