The ultimate goal of protein modeling is to predict a structure from its sequence with an
accuracy that is comparable to the best results achieved experimentally. This would allow users …

Life expectancy and quality of life for those born with congenital heart disease (CHD) have
greatly improved over the past 3 decades. While representing a great advance for these …

Background : Anticoagulation for mechanical heart valves during pregnancy is essential to
prevent thromboembolic events. Each regimen has drawbacks with regard to maternal or fetal …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through March 1, 2020. Searches …

The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1
mutations are associated with PARK7, a monogenic form of human parkinsonism. The function …

Aim This executive summary of the valvular heart disease guideline provides recommendations
for clinicians to diagnose and manage valvular heart disease as well as supporting …

One of the conclusions drawn at the CASP4 meeting in Asilomar was that applying various
force fields during refinement of template‐based models tends to move predictions in the …

A correct alignment is an essential requirement in homology modeling. Yet in order to
bridge the structural gap between template and target, which may not only involve loop …

Today's graphics processing units (GPUs) compose the scene from individual triangles. As
about 320 triangles are needed to approximate a single sphere—an atom—in a convincing …

… In addition to a hydrogen-bonding network optimizer,18 a new method for pKa prediction in
protein crystals was required to assign the protonation states of ionizable groups (Krieger et …