User profiles for E. Desjardins

Eric M. Desjardins

McMaster University
Verified email at mcmaster.ca
Cited by 2021

Treatment of nonalcoholic fatty liver disease: role of AMPK

BK Smith, K Marcinko, EM Desjardins… - American Journal …, 2016 - journals.physiology.org
Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important
risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic …

Emerging role of AMPK in brown and beige adipose tissue (BAT): implications for obesity, insulin resistance, and type 2 diabetes

EM Desjardins, GR Steinberg - Current diabetes reports, 2018 - Springer
Purpose of Review The global prevalence of type 2 diabetes (T2D) is escalating at alarming
rates, demanding the development of additional classes of therapeutics to further reduce the …

Evidence-based strategies to build community food security.

C McCullum, E Desjardins, VI Kraak, P Ladipo… - 2005 - cabidigitallibrary.org
This article describes a 3-stage continuum of evidence-based strategies and activities that
can be used by dietetics professionals to establish community food security. Stage 1 creates …

[HTML][HTML] The antigenic structure of the HIV gp120 envelope glycoprotein

R Wyatt, PD Kwong, E Desjardins, RW Sweet… - Nature, 1998 - nature.com
… The ℒA, ℒC, ℒD and ℒE surface loops 12 are shown. The position of the Phe 43 cavity
involved in CD4 binding is indicated by an asterisk. The gp120 surface implicated in binding to …

[PDF][PDF] Lack of adipocyte AMPK exacerbates insulin resistance and hepatic steatosis through brown and beige adipose tissue function

EP Mottillo, EM Desjardins, JD Crane, BK Smith… - Cell metabolism, 2016 - cell.com
Brown (BAT) and white (WAT) adipose tissues play distinct roles in maintaining whole-body
energy homeostasis, and their dysfunction can contribute to non-alcoholic fatty liver disease (…

[PDF][PDF] Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

…, JM Leroux, P Mohammadi-Shemirani, EM Desjardins… - Cell Metabolism, 2022 - cell.com
Elevated liver de novo lipogenesis contributes to non-alcoholic steatohepatitis (NASH) and
can be inhibited by targeting acetyl-CoA carboxylase (ACC). However, hypertriglyceridemia …

[HTML][HTML] GDF15 promotes weight loss by enhancing energy expenditure in muscle

…, MJT Jabile, CA Pileggi, S Rehal, EM Desjardins… - Nature, 2023 - nature.com
Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes 1 . Despite …

Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein

J Cao, N Sullivan, E Desjardin, C Parolin… - Journal of …, 1997 - Am Soc Microbiol
A human immunodeficiency virus type 1 (HIV-1) mutant lacking the V1 and V2 variable
loops in the gp120 exterior envelope glycoprotein replicated in Jurkat lymphocytes with only …

A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5

…, H Choe, L Vaca, K Martin, Y Sun, E Desjardins… - Journal of …, 1998 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) requires the presence of specific chemokine
receptors in addition to CD4 to enter target cells. The chemokine receptor CCR5 is used by …

[PDF][PDF] Muramyl dipeptide-based postbiotics mitigate obesity-induced insulin resistance via IRF4

…, KP Foley, E Denou, BK Smith, EM Desjardins… - Cell metabolism, 2017 - cell.com
Intestinal dysbiosis contributes to obesity and insulin resistance, but intervening with antibiotics,
prebiotics, or probiotics can be limited by specificity or sustained changes in microbial …