User profiles for Douglas H. Smith

Douglas H. Smith

Prof. Neurosurgery, Director - Center for Brain Injury and Repair, University of Pennsylvania
Verified email at upenn.edu
Cited by 34859

Axonal pathology in traumatic brain injury

VE Johnson, W Stewart, DH Smith - Experimental neurology, 2013 - Elsevier
Over the past 70 years, diffuse axonal injury (DAI) has emerged as one of the most common
and important pathological features of traumatic brain injury (TBI). Axons in the white matter …

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

…, JE Stewart, FD Begbie, JQ Trojanowski, DH Smith… - Brain, 2013 - academic.oup.com
A single traumatic brain injury is associated with an increased risk of dementia and, in a
proportion of patients surviving a year or more from injury, the development of hallmark …

Designing CD4 immunoadhesins for AIDS therapy

…, FM Wurm, JE Groopman, S Broder, DH Smith - Nature, 1989 - nature.com
A newly-constructed antibody-like molecule containing the gp!20-binding domain of the
receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its …

Expression of active human factor VIII from recombinant DNA clones

…, DL Eaton, J Gitschier, B Keyt, PH Seeburg, DH Smith… - Nature, 1984 - nature.com
DNA clones encoding the complete 2,351 amino acid sequence for human factor VIII have
been isolated and used to produce biologically active factor VIII in cultured mammalian cells. …

Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus

MA Muesing, DH Smith, CD Cabradilla, CV Benton… - Nature, 1985 - nature.com
The 9,213-nucleotide structure of the AIDS/ lymphadenopathy virus has been determined
from molecular clones representing the integrated provirus and viral RNA. The sequence …

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

LA Lasky, G Nakamura, DH Smith, C Fennie… - Cell, 1987 - cell.com
The primary event in the infection of cells by HIV is the interaction between the viral envelope
glycoprotein, gp120, and its cellular receptor, CD4. A recombinant form of gp120 was …

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

…, F Kirschenbaum, M Noguchi, DH Smith… - Nature …, 1997 - nature.com
We constructed two megabase-sized YACs containing large contiguous fragments of the
human heavy and kappa (κ) light chain immunoglobulin (Ig) loci in nearly germline …

Diffuse axonal injury in head trauma

DH Smith, DF Meaney, WH Shull - The Journal of head trauma …, 2003 - journals.lww.com
Background: Diffuse axonal injury (DAI) is one of the most common and important pathologic
features of traumatic brain injury (TBI). The susceptibility of axons to mechanical injury …

In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity

RL Willey, DH Smith, LA Lasky, TS Theodore… - Journal of …, 1988 - Am Soc Microbiol
Site-specific mutagenesis was used to introduce amino acid substitutions at the asparagine
codons of four conserved potential N-linked glycosylation sites within the gp120 envelope …

Selective vulnerability of dentate hilar neurons following traumatic brain injury: a potential mechanistic link between head trauma and disorders of the hippocampus

DH Lowenstein, MJ Thomas, DH Smith… - Journal of …, 1992 - Soc Neuroscience
Despite intensive study, the neurobiological basis of epilepsy and persistent memory
impairment following traumatic head injury remains unknown. Since abnormalities of the …