[HTML][HTML] Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis

…, V Leung, D Westwood, DR MacFadden… - Clinical microbiology …, 2020 - Elsevier
Background Bacterial co-pathogens are commonly identified in viral respiratory infections
and are important causes of morbidity and mortality. The prevalence of bacterial infection in …

[HTML][HTML] Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis

…, D Westwood, N Daneman, DR MacFadden - Clinical microbiology …, 2021 - Elsevier
Background The proportion of patients infected with SARS-CoV-2 that are prescribed
antibiotics is uncertain, and may contribute to patient harm and global antibiotic resistance. …

Antibiotic resistance increases with local temperature

DR MacFadden, SF McGough, D Fisman… - Nature Climate …, 2018 - nature.com
Bacteria that cause infections in humans can develop or acquire resistance to antibiotics
commonly used against them 1, 2. Antimicrobial resistance (in bacteria and other microbes) …

[HTML][HTML] Antibiotic resistance associated with the COVID-19 pandemic: a systematic review and meta-analysis

…, S Bertagnolio, S Raybardhan, DR MacFadden… - Clinical Microbiology …, 2023 - Elsevier
Background COVID-19 and antimicrobial resistance (AMR) are two intersecting global public
health crises. Objective We aimed to describe the impact of the COVID-19 pandemic on …

Impact of reported beta-lactam allergy on inpatient outcomes: a multicenter prospective cohort study

DR MacFadden, A LaDelfa, J Leen… - Clinical Infectious …, 2016 - academic.oup.com
Background. Reported allergy to beta-lactam antibiotics is common and often leads to
unnecessary avoidance in patients who could tolerate these antibiotics. We prospectively …

The distribution of antibiotic use and its association with antibiotic resistance

SW Olesen, ML Barnett, DR MacFadden… - Elife, 2018 - elifesciences.org
10.7554/eLife.39435.001 Antibiotic use is a primary driver of antibiotic resistance. However,
antibiotic use can be distributed in different ways in a population, and the association …

[HTML][HTML] Predictors and microbiology of respiratory and bloodstream bacterial infection in patients with COVID-19: living rapid review update and meta-regression

…, D Westwood, N Daneman, DR MacFadden… - Clinical Microbiology …, 2022 - Elsevier
Background The prevalence of bacterial infection in patients with COVID-19 is low, however,
empiric antibiotic use is high. Risk stratification may be needed to minimize unnecessary …

Sex differences in implantable cardioverter-defibrillator outcomes: findings from a prospective defibrillator database

DR MacFadden, E Crystal, AD Krahn… - Annals of internal …, 2012 - acpjournals.org
Background: Sex differences in the use and outcomes of implantable cardioverter-defibrillators
(ICDs) have not been fully studied. Objective: To examine potential sex differences in ICD …

Prevalence and mortality associated with bloodstream organisms: a population-wide retrospective cohort study

…, KL Schwartz, DR MacFadden… - Journal of Clinical …, 2022 - Am Soc Microbiol
Bloodstream infections (BSIs) represent a substantial mortality risk, yet most studies are limited
to select pathogens or populations. The aim of this study was to describe the population-…

[HTML][HTML] Rapid inference of antibiotic resistance and susceptibility by genomic neighbour typing

K Břinda, A Callendrello, KC Ma, DR MacFadden… - Nature …, 2020 - nature.com
Surveillance of drug-resistant bacteria is essential for healthcare providers to deliver
effective empirical antibiotic therapy. However, traditional molecular epidemiology does not …