User profiles for Denis Roy

Denis Roy

- Verified email at inaf.ulaval.ca - Cited by 12188

Denis Claude Roy

- Verified email at umontreal.ca - Cited by 11380

Canadian Implantable Defibrillator Study (CIDS) a randomized trial of the implantable cardioverter defibrillator against amiodarone

SJ Connolly, M Gent, RS Roberts, P Dorian, D Roy… - Circulation, 2000 - Am Heart Assoc
Background—Patients surviving ventricular fibrillation (VF) or sustained ventricular
tachycardia (VT) are at a high risk of death due to a recurrence of arrhythmia. The implantable …

[HTML][HTML] Rhythm control versus rate control for atrial fibrillation and heart failure

D Roy, M Talajic, S Nattel, DG Wyse… - … England Journal of …, 2008 - Mass Medical Soc
Background It is common practice to restore and maintain sinus rhythm in patients with atrial
fibrillation and heart failure. This approach is based in part on data indicating that atrial …

[HTML][HTML] Amiodarone to prevent recurrence of atrial fibrillation

D Roy, M Talajic, P Dorian, S Connolly… - … England Journal of …, 2000 - Mass Medical Soc
Background The restoration and maintenance of sinus rhythm is a desirable goal in patients
with atrial fibrillation, because the prevention of recurrences can improve cardiac function …

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

…, C Haworth, R Hock, M Loh, C Felix, DC Roy… - Nature …, 1999 - nature.com
Familial platelet disorder with predisposition to acute myelogenous leukaemia (FPD/AML,
MIM 601399) is an autosomal dominant disorder characterized by qualitative and quantitative …

A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp …

FF Anhê, D Roy, G Pilon, S Dudonné, S Matamoros… - Gut, 2015 - gut.bmj.com
Objective The increasing prevalence of obesity and type 2 diabetes (T2D) demonstrates the
failure of conventional treatments to curb these diseases. The gut microbiota has been put …

[HTML][HTML] Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma

…, AS Freedman, D Neuberg, DC Roy… - … England Journal of …, 1991 - Mass Medical Soc
Background. The use of autologous bone marrow transplantation is increasing in the
management of advanced cancers. Many investigators have attempted to "purge" autologous …

[HTML][HTML] Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter

…, SJ Connolly, HJGM Crijns, D Roy… - … England Journal of …, 2007 - Mass Medical Soc
Background Amiodarone is effective in maintaining sinus rhythm in atrial fibrillation but is
associated with potentially serious toxic effects. Dronedarone is a new antiarrhythmic agent …

[HTML][HTML] miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts

…, J Cortes, P Hokland, CS Huettner, R Bhatia, DC Roy… - Cell, 2010 - cell.com
MicroRNAs and heterogeneous ribonucleoproteins (hnRNPs) are posttranscriptional gene
regulators that bind mRNA in a sequence-specific manner. Here, we report that loss of miR-…

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

…, DJHF Knapp, P Miller, M Ngom, S Imren, DC Roy… - Science, 2014 - science.org
The small number of hematopoietic stem and progenitor cells in cord blood units limits their
widespread use in human transplant protocols. We identified a family of chemically related …

[HTML][HTML] The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

…, S Liu, H Mao, JS Chang, A Galietta, A Uttam, DC Roy… - Cancer cell, 2005 - cell.com
The oncogenic BCR/ABL kinase activity induces and maintains chronic myelogenous
leukemia (CML). We show here that, in BCR/ABL-transformed cells and CML blast crisis (CML-BC) …