Background The management of warfarin therapy is complicated by a wide variation among
patients in drug response. Variants in the gene encoding vitamin K epoxide reductase …

Background The use of anticoagulant therapy during pregnancy is challenging because of
the potential for both fetal and maternal complications. This guideline focuses on the …

Background High-quality anticoagulation management is required to keep these narrow
therapeutic index medications as effective and safe as possible. This article focuses on the …

… Author Affiliations: Pharmaceutical Outcomes Research and Policy Program (Drs Higashi
and Veenstra), Institute for Public Health Genetics (Dr Veenstra), and Department of Pharmacy …

ContextAdverse drug reactions are a significant cause of morbidity and mortality. Although
many adverse drug reactions are considered nonpreventable, recent developments suggest …

The burden of hepatitis B virus (HBV) disease and efforts to control infection will determine
the future size of the population requiring treatment of HBV infection. To quantify the current …

Purpose: Bloodstream infections related to use of catheters, particularly central-line catheters,
are an important cause of patient morbidity, mortality, and increased health care costs. …

ContextCentral venous catheters impregnated with chlorhexidine and silver sulfadiazine have
recently been introduced for the prevention of catheter-related infections. However, there …

As more research studies incorporate next-generation sequencing (including whole-genome
or whole-exome sequencing), investigators and institutional review boards face difficult …

Warfarin dosing is correlated with polymorphisms in vitamin K epoxide reductase complex 1
(VKORC1) and the cytochrome P450 2C9 (CYP2C9) genes. Recently, the FDA revised …