Background The Randomized Aldactone Evaluation Study (RALES) demonstrated that
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …

Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …

Background Prior studies suggest that unintended medication discrepancies that represent
errors are common at the time of hospital admission. These errors are particularly worthy of …

ContextDrug-drug interactions are a preventable cause of morbidity and mortality, yet their
consequences in the community are not well characterized.ObjectiveTo determine whether …

Background This study evaluated the risk of long-term analgesic use after low-risk surgery
in older adults not previously prescribed analgesics. Methods We conducted a retrospective …

The Stanford–Lancet Commission on the North American Opioid Crisis was formed in response
to soaring opioid-related morbidity and mortality in the USA and Canada over the past …

Background Suicide is a leading cause of death, and rates are especially high among the
elderly. Medical illnesses may predispose to suicide, but few controlled studies have …

Background Opioids are widely prescribed for chronic nonmalignant pain, often at doses
exceeding those recommended in clinical practice guidelines. However, the risk-benefit ratio of …

Methods In developing this guideline, the steering committee followed standards for trustworthy
guidelines. 15 We included innovative approaches for key standards such as patient …

Objective To characterise whether some selective serotonin reuptake inhibitor (SSRI)
antidepressants reduce tamoxifen’s effectiveness by inhibiting its bioactivation by cytochrome …