We previously identified mutations in the Lpin1 gene, encoding lipin-1, as the underlying
cause of lipodystrophy in the fatty liver dystrophy (fld) mutant mouse. Lipin-1 is normally …

High-fat feeding induces insulin resistance and increases the risk for the development of
diabetes and coronary artery disease. Glucocorticoids exacerbate this hyperinsulinemic state, …

This review has discussed some metabolic and endocrine changes that can be associated
with a stress type of metabolism, diabetes, obesity, hypertension, smoking and the …

Recent studies have identified factors responsible for angiogenesis within developing
tumors, but mediators of vessel formation at sites of trauma, injury, and wound healing are not …

Lipid phosphates initiate key signaling cascades in cell activation. Lysophosphatidate (LPA)
and sphingosine 1‐phosphate (S1P) are produced by activated platelets. LPA is also …

To determine the mechanism by which the (n-3) fatty acids (FA) eicosapentaenoic acid (EPA)
and docosahexaenoic acid (DHA) decrease proliferation and induce apoptosis in MDA-MB-…

Phosphatidate phosphohydrolase (PAP) 1 was first identified as being involved in
glycerolipid synthesis (1). A second PAP activity (PAP-2) was subsequently characterized in …

Lipid phosphate phosphatases (LPPs) regulate cell signaling by modifying the concentrations
of lipid phosphates versus their dephosphorylated products. The ecto-activity regulates …

Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis
through the conversion of phosphatidate to diacylglycerol, the immediate precursor of …

Ceramide and ceramide-1-phosphate are sphingolipid analogues of diacylglycerol and
phosphatidate, respectively, and they are putative second messengers of agonist-stimulated …