Likelihood ratios with confidence: sample size estimation for diagnostic test studies

DL Simel, GP Samsa, DB Matchar - Journal of clinical epidemiology, 1991 - Elsevier
Confidence intervals are important summary measures that provide useful information from
clinical investigations, especially when comparing data from different populations or sites. …

Does this woman have an acute uncomplicated urinary tract infection?

S Bent, BK Nallamothu, DL Simel, SD Fihn, S Saint - Jama, 2002 - jamanetwork.com
ContextSymptoms suggestive of acute urinary tract infection (UTI) constitute one of the most
common reasons for women to visit clinicians. Although the clinical encounter typically …

Is this patient hypovolemic?

S McGee, WB Abernethy III, DL Simel - Jama, 1999 - jamanetwork.com
ObjectiveTo review, systematically, the physical diagnosis of hypovolemia in adults.MethodsWe
searched MEDLINE (January 1966-November 1997), personal files, and bibliographies …

Does this patient have delirium?: value of bedside instruments

CL Wong, J Holroyd-Leduc, DL Simel, SE Straus - Jama, 2010 - jamanetwork.com
Context Delirium occurs in many hospitalized older patients and has serious consequences
including increased risk for death and admission to long-term care. Despite its importance, …

Is this patient having a myocardial infarction?

AA Panju, BR Hemmelgarn, GH Guyatt, DL Simel - Jama, 1998 - jamanetwork.com
When faced with a patient with acute chest pain, clinicians must distinguish myocardial
infarction (MI) from all other causes of acute chest pain. If MI is suspected, current therapeutic …

Does this patient have influenza?

SA Call, MA Vollenweider, CA Hornung, DL Simel… - Jama, 2005 - jamanetwork.com
ContextInfluenza vaccination lowers, but does not eliminate, the risk of influenza. Making a
reliable, rapid clinical diagnosis is essential to appropriate patient management that may be …

Does the clinical examination predict lower extremity peripheral arterial disease?

NA Khan, SA Rahim, SS Anand, DL Simel, A Panju - Jama, 2006 - jamanetwork.com
ContextLower extremity peripheral arterial disease (PAD) is common and associated with
significant increases in morbidity and mortality. Physicians typically depend on the clinical …

Does this patient have a torn meniscus or ligament of the knee?: value of the physical examination

DH Solomon, DL Simel, DW Bates, JN Katz… - Jama, 2001 - jamanetwork.com
ContextWhile most meniscal or ligamentous knee injuries heal with nonoperative treatments,
a subset should be treated with arthroscopic or open surgery.ObjectiveTo analyze the …

Is this patient having a stroke?

LB Goldstein, DL Simel - Jama, 2005 - jamanetwork.com
ContextPatients suspected of having a stroke or transient ischemic attack require accurate
assessment for appropriate acute treatment and use of secondary preventive interventions.…

Does this patient have obstructive sleep apnea?: The Rational Clinical Examination systematic review

KA Myers, M Mrkobrada, DL Simel - Jama, 2013 - jamanetwork.com
Importance Obstructive sleep apnea is a common disease, responsible for daytime sleepiness.
Prior to referring patients for definitive testing, the likelihood of obstructive sleep apnea …