User profiles for David Gladstone

David J. Gladstone

Sunnybrook Health Sciences Centre, University of Toronto
Verified email at sunnybrook.ca
Cited by 35617

[HTML][HTML] Atrial fibrillation in patients with cryptogenic stroke

DJ Gladstone, M Spring, P Dorian… - … England Journal of …, 2014 - Mass Medical Soc
Background Atrial fibrillation is a leading preventable cause of recurrent stroke for which
early detection and treatment are critical. However, paroxysmal atrial fibrillation is often …

The Fugl-Meyer assessment of motor recovery after stroke: a critical review of its measurement properties

DJ Gladstone, CJ Danells… - … and neural repair, 2002 - journals.sagepub.com
Measurement of recovery after stroke is becoming increasingly important with the advent of
new treatment options under investigation in stroke rehabilitation research. The Fugl-Meyer …

Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

DJ Gladstone, SE Black, AM Hakim - Stroke, 2002 - Am Heart Assoc
Background— Neuroprotective drugs for acute stroke have appeared to work in animals,
only to fail when tested in humans. With the failure of so many clinical trials, the future of …

Screening for atrial fibrillation: a report of the AF-SCREEN International Collaboration

…, DA Fitzmaurice, L Friberg, BJ Gersh, DJ Gladstone… - Circulation, 2017 - Am Heart Assoc
Approximately 10% of ischemic strokes are associated with atrial fibrillation (AF) first diagnosed
at the time of stroke. Detecting asymptomatic AF would provide an opportunity to prevent …

The 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society comprehensive guidelines for the management of atrial fibrillation

…, CC Cheung, JL Cox, P Dorian, DJ Gladstone… - Canadian Journal of …, 2020 - Elsevier
The Canadian Cardiovascular Society (CCS) atrial fibrillation (AF) guidelines program was
developed to aid clinicians in the management of these complex patients, as well as to …

Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational …

…, S Tymchuk, S Subramaniam, DJ Gladstone… - The Lancet …, 2012 - thelancet.com
Background In patients with intracerebral haemorrhage (ICH), early haemorrhage expansion
affects clinical outcome. Haemostatic treatment reduces haematoma expansion, but fails to …

CT angiography “spot sign” predicts hematoma expansion in acute intracerebral hemorrhage

R Wada, RI Aviv, AJ Fox, DJ Sahlas, DJ Gladstone… - Stroke, 2007 - Am Heart Assoc
Background and Purpose— Morbidity and mortality in spontaneous intracerebral hemorrhage
(ICH) are correlated with hematoma progression. We hypothesized that the presence of …

Potentially preventable strokes in high-risk patients with atrial fibrillation who are not adequately anticoagulated

DJ Gladstone, E Bui, J Fang, A Laupacis, MP Lindsay… - Stroke, 2009 - Am Heart Assoc
Background and Purpose— Warfarin is the most effective stroke prevention medication for
high-risk individuals with atrial fibrillation, yet it is often underused. This study examined the …

Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised …

…, F Bala, MK Horn, G Stotts, MD Hill, DJ Gladstone… - The Lancet, 2022 - thelancet.com
Background Intravenous thrombolysis with alteplase bolus followed by infusion is a global
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …

2014 focused update of the Canadian Cardiovascular Society Guidelines for the management of atrial fibrillation

…, LB Mitchell, L Macle, IG Stiell, D Gladstone… - Canadian Journal of …, 2014 - Elsevier
Atrial fibrillation (AF) is an extremely common clinical problem with an important population
morbidity and mortality burden. The management of AF is complex and fraught with many …