User profiles for Dale Corbett

Dale Corbett

Professor of Neurosciences, University of Ottawa
Verified email at uottawa.ca
Cited by 20995

Plasticity during stroke recovery: from synapse to behaviour

TH Murphy, D Corbett - Nature reviews neuroscience, 2009 - nature.com
Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which
results in damage to neuronal networks and the impairment of sensation, movement or …

Efficacy of rehabilitative experience declines with time after focal ischemic brain injury

J Biernaskie, G Chernenko, D Corbett - Journal of Neuroscience, 2004 - Soc Neuroscience
To maximize the effectiveness of rehabilitative therapies after stroke, it is critical to determine
when the brain is most responsive (ie, plastic) to sensorimotor experience after injury and to …

Getting neurorehabilitation right: what can be learned from animal models?

…, ST Carmichael, D Corbett… - … and neural repair, 2012 - journals.sagepub.com
Animal models suggest that a month of heightened plasticity occurs in the brain after stroke,
accompanied by most of the recovery from impairment. This period of peri-infarct and remote …

Agreed definitions and a shared vision for new standards in stroke recovery research: the stroke recovery and rehabilitation roundtable taskforce

…, LA Boyd, ST Carmichael, D Corbett… - … Journal of Stroke, 2017 - journals.sagepub.com
The first Stroke Recovery and Rehabilitation Roundtable established a game changing set
of new standards for stroke recovery research. Common language and definitions were …

Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury

J Biernaskie, D Corbett - Journal of Neuroscience, 2001 - Soc Neuroscience
Chronic impairment of forelimb and digit movement is a common problem after stroke that is
resistant to therapy. Previous studies have demonstrated that enrichment improves …

Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection

F Colbourne, D Corbett - Journal of Neuroscience, 1995 - Soc Neuroscience
In the gerbil, brief global forebrain ischemia induces profound habituation and working
memory impairments that stem from delayed hippocampal CA1 death. Short duration …

Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases

…, MR Del Bigio, PH Larsen, D Corbett… - Annals of …, 2003 - Wiley Online Library
Intracerebral hemorrhage (ICH) is characterized by parenchymal hematoma formation with
surrounding inflammation. Matrix metalloproteinases (MMPs) have been implicated in the …

Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil

F Colbourne, D Corbett - Brain research, 1994 - Elsevier
Global ischemia, in the gerbil, produces profound hippocampal CA1 loss which leads to
functional abnormalities (eg habituation impairment). In experiment 1, gerbils were subjected to …

Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats

…, V Windle, CL MacLellan, N White, JJ Doré, D Corbett - Stroke, 2009 - Am Heart Assoc
Background and Purpose— Brain-derived neurotrophic factor (BDNF) is involved in neuronal
survival, synaptic plasticity, learning and memory, and neuroplasticity. Further, exogenous …

Intracranial self-stimulation in relation to the ascending dopaminergic systems of the midbrain: a moveable electrode mapping study

D Corbett, RA Wise - Brain research, 1980 - Elsevier
Chronically implanted moveable electrodes were used to map the midbrain and caudal
diencephalon for intracranial self-stimulation in relation to the ascending dopamine systems as …