User profiles for D. Robert Siemens

D.Robert Siemens

Queens University
Verified email at kingstonhsc.ca
Cited by 8237

Molecular profiling in muscle‐invasive bladder cancer: more than the sum of its parts

…, CL Jackson, JMS Bartlett, DR Siemens… - The Journal of …, 2019 - Wiley Online Library
Bladder cancers are biologically and clinically heterogeneous. Recent large‐scale
transcriptomic profiling studies focusing on life‐threatening muscle‐invasive cases have …

Depression and prostate cancer: A focused review for the clinician

…, DA Tripp, S Rajan, DP Leong, DR Siemens - … Oncology: Seminars and …, 2019 - Elsevier
Prostate cancer is the most common malignancy among men. Given its prevalence and
relatively low mortality rates, several biopsychosocial survivorship issues have garnered recent …

A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells

IB Barsoum, CA Smallwood, DR Siemens, CH Graham - Cancer research, 2014 - AACR
Immune escape is a fundamental trait of cancer in which mechanistic knowledge is incomplete.
Here, we describe a novel mechanism by which hypoxia contributes to tumoral immune …

Active surveillance of small renal masses: progression patterns of early stage kidney cancer

…, J Basiuk, CG Morash, SE Pautler, DR Siemens… - European urology, 2011 - Elsevier
Background Most early stage kidney cancers are renal cell carcinomas (RCCs), and most
are diagnosed incidentally by imaging as small renal masses (SRMs). Indirect evidence …

Sex differences in bladder cancer immunobiology and outcomes: a collaborative review with implications for treatment

…, X Li, AM Kamat, PC Black, DR Siemens - European Urology …, 2020 - Elsevier
Context Urothelial carcinoma of the bladder (UCB) exhibits significant sexual dimorphism in
the incidence, etiology, and response to intravesical immunotherapy. Environmental factors …

[HTML][HTML] A survey on the attitudes towards research in medical school

DR Siemens, S Punnen, J Wong, N Kanji - BMC medical education, 2010 - Springer
Background An observed decrease of physician scientists in medical practice has generated
much recent interest in increasing the exposure of research programs in medical school. …

Efficacy and safety of enzalutamide versus bicalutamide for patients with metastatic prostate cancer (TERRAIN): a randomised, double-blind, phase 2 study

…, A Villers, L Klotz, DR Siemens, D Phung… - The Lancet …, 2016 - thelancet.com
Background Enzalutamide is an oral androgen-receptor inhibitor that has been shown to
improve survival in two placebo-controlled phase 3 trials, and is approved for patients with …

Mechanisms of hypoxia-mediated immune escape in cancer

IB Barsoum, M Koti, DR Siemens, CH Graham - Cancer research, 2014 - AACR
An important aspect of malignant progression is the acquired ability of tumor cells to avoid
recognition and destruction by the immune system (immune escape). Clinical cancer …

Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide

…, TK Hamilton, X Li, T Cotechini, EA Miles, DR Siemens… - Cancer research, 2011 - AACR
One key to malignant progression is the acquired ability of tumor cells to escape immune-mediated
lysis. Whereas tumor hypoxia is known to play a causal role in cancer metastasis and …

[HTML][HTML] Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis

…, SK Macdonald-Goodfellow, M Petroff, DR Siemens… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The ability of tumor cells to avoid immune destruction (immune escape) as well as their
acquired resistance to anti-cancer drugs constitute important barriers to the successful …