User profiles for D. Robert Siemens
D.Robert SiemensQueens University Verified email at kingstonhsc.ca Cited by 8237 |
Molecular profiling in muscle‐invasive bladder cancer: more than the sum of its parts
Bladder cancers are biologically and clinically heterogeneous. Recent large‐scale
transcriptomic profiling studies focusing on life‐threatening muscle‐invasive cases have …
transcriptomic profiling studies focusing on life‐threatening muscle‐invasive cases have …
Depression and prostate cancer: A focused review for the clinician
Prostate cancer is the most common malignancy among men. Given its prevalence and
relatively low mortality rates, several biopsychosocial survivorship issues have garnered recent …
relatively low mortality rates, several biopsychosocial survivorship issues have garnered recent …
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
IB Barsoum, CA Smallwood, DR Siemens, CH Graham - Cancer research, 2014 - AACR
Immune escape is a fundamental trait of cancer in which mechanistic knowledge is incomplete.
Here, we describe a novel mechanism by which hypoxia contributes to tumoral immune …
Here, we describe a novel mechanism by which hypoxia contributes to tumoral immune …
Active surveillance of small renal masses: progression patterns of early stage kidney cancer
…, J Basiuk, CG Morash, SE Pautler, DR Siemens… - European urology, 2011 - Elsevier
Background Most early stage kidney cancers are renal cell carcinomas (RCCs), and most
are diagnosed incidentally by imaging as small renal masses (SRMs). Indirect evidence …
are diagnosed incidentally by imaging as small renal masses (SRMs). Indirect evidence …
Sex differences in bladder cancer immunobiology and outcomes: a collaborative review with implications for treatment
Context Urothelial carcinoma of the bladder (UCB) exhibits significant sexual dimorphism in
the incidence, etiology, and response to intravesical immunotherapy. Environmental factors …
the incidence, etiology, and response to intravesical immunotherapy. Environmental factors …
[HTML][HTML] A survey on the attitudes towards research in medical school
DR Siemens, S Punnen, J Wong, N Kanji - BMC medical education, 2010 - Springer
Background An observed decrease of physician scientists in medical practice has generated
much recent interest in increasing the exposure of research programs in medical school. …
much recent interest in increasing the exposure of research programs in medical school. …
Efficacy and safety of enzalutamide versus bicalutamide for patients with metastatic prostate cancer (TERRAIN): a randomised, double-blind, phase 2 study
…, A Villers, L Klotz, DR Siemens, D Phung… - The Lancet …, 2016 - thelancet.com
Background Enzalutamide is an oral androgen-receptor inhibitor that has been shown to
improve survival in two placebo-controlled phase 3 trials, and is approved for patients with …
improve survival in two placebo-controlled phase 3 trials, and is approved for patients with …
Mechanisms of hypoxia-mediated immune escape in cancer
An important aspect of malignant progression is the acquired ability of tumor cells to avoid
recognition and destruction by the immune system (immune escape). Clinical cancer …
recognition and destruction by the immune system (immune escape). Clinical cancer …
Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide
…, TK Hamilton, X Li, T Cotechini, EA Miles, DR Siemens… - Cancer research, 2011 - AACR
One key to malignant progression is the acquired ability of tumor cells to escape immune-mediated
lysis. Whereas tumor hypoxia is known to play a causal role in cancer metastasis and …
lysis. Whereas tumor hypoxia is known to play a causal role in cancer metastasis and …
[HTML][HTML] Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis
…, SK Macdonald-Goodfellow, M Petroff, DR Siemens… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The ability of tumor cells to avoid immune destruction (immune escape) as well as their
acquired resistance to anti-cancer drugs constitute important barriers to the successful …
acquired resistance to anti-cancer drugs constitute important barriers to the successful …