Although the concept of the coagulation cascade represented a significant advance in the
understanding of coagulation and served for many years as a useful model, more recent …

In 1977 WHO published in the Bulletin a Memorandum on Methods for the Detection of
Haemophilia Carriers. This was produced following a WHO/WFH (World Federation of …

Two patients developed catastrophic multicentric skin necrosis while receiving warfarin to
treat venous thromboembolism complicated by immune‐mediated heparin‐induced …

Report of a joint WHO/WFH meeting on the control of haemophi... : Blood Coagulation &
Fibrinolysis Report of a joint WHO/WFH meeting on the control of haemophilia: carrier detection …

Spontaneous mutation provides the substrate for evolution on one hand and for genetic
susceptibility to disease on the other hand. X-linked diseases such as hemophilia B offer an …

Two cases of systemic lupus erythematosus with hemodynamically significant mitral valve
dysfunction and associated lupus anticoagulant are reported. Both patients underwent valve …

The development of antibodies to a previously unexpressed protein product may limit the
success of human gene therapy approaches. We inserted B-domain-deleted factor VIII (FVIII) …

The data base below lists known point mutations and short deletions and additions in the
factor IX gene, which cause the bleeding disorder haemophilia B or Christmas disease (for …

Studies have shown that hemophilia B (Christmas disease; factor IX deficiency) results from
many different mutations in the factor IX gene, of which greater than 95% are single …

The genetic basis of familial Meniere's disease (MD) is unclear. We present a genetic
investigation of six individuals in two families with familial MD. Linkage analysis was performed …