Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to
biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative …

‘Reactive oxygen species’ (ROS) is a generic term that defines a wide variety of oxidant
molecules with vastly different properties and biological functions that range from signalling to …

‘Reactive oxygen species’ (ROS) is an umbrella term for an array of derivatives of molecular
oxygen that occur as a normal attribute of aerobic life. Elevated formation of the different …

Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria.
Overexpression of Bcl-2 prevents cells from undergoing apoptosis in response to a variety …

Background Mortality statistics are fundamental to public health decision making. Mortality
varies by time and location, and its measurement is affected by well known biases that have …

Oxidative stress is often defined as an imbalance of pro-oxidants and antioxidants, which
can be quantified in humans as the redox state of plasma GSH/GSSG. Plasma GSH redox in …

… Go, DP Jones, unpublished). This suggests that perhaps 80–90% of protein thiols are
relatively inert to redox reactions. Extrapolation of the 10–20% readily oxidized thiols to the full …

A sudden increase in permeability of the inner mitochondrial membrane, the so-called
mitochondrial permeability transition, is a common feature of apoptosis and is mediated by the …

Mitochondrial cytochrome c (cyt c) has been found to have dual functions in controlling both
cellular energetic metabolism and apoptosis. Through interaction with apoptotic protease …

Activation of apoptosis is associated with generation of reactive oxygen species. The present
research shows that superoxide is produced by mitochondria isolated from apoptotic cells …