Impact of recess on classroom behavior: Group effects and individual differences

OS Jarrett, DM Maxwell, C Dickerson… - The Journal of …, 1998 - Taylor & Francis
The purpose of this research was to determine the effect of a recess break on classroom
behavior, specifically working, fidgeting, and listlessness. A southern urban school district with a …

The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds

DM Maxwell - Toxicology and applied pharmacology, 1992 - Elsevier
The ability of endogenous carboxylesterase (CaE) to protect against the lethal effects of a
variety of organophosphorus (OP) compounds was examined in rats. The in vivo protection …

Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates.

CA Broomfield, DM Maxwell, RP Solana… - … of Pharmacology and …, 1991 - ASPET
Butyrylcholinesterase (BuChE) was examined as an in vivo exogenous scavenger for highly
toxic organophosphorus (OP) poisons. Protection studies with equine BuChE were carried …

The effect of carboxylesterase inhibition on interspecies differences in soman toxicity

DM Maxwell, KM Brecht, BL O'Neill - Toxicology letters, 1987 - Elsevier
Subcutaneous administration of 2 mg/kg cresylbenzodioxaphosphorin oxide (CBDP) produced
complete inhibition of carboxylesterase activity in plasma and lung of mice, rats, guinea …

Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys

DE Lenz, DM Maxwell, I Koplovitz, CR Clark… - Chemico-biological …, 2005 - Elsevier
… JH McDonough, DM Penetar, The effects of cholinergic blocking agents and anticholinesterase
compounds on memory, learning and performance, in: MY Spiegelstein, A. Levy (Eds.), …

Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds?

DM Maxwell, KM Brecht, I Koplovitz, RE Sweeney - Archives of toxicology, 2006 - Springer
The hypothesis that acetylcholinesterase (AChE) inhibition is the mechanism of toxicity of
organophosphorus (OP) compounds was examined by mathematically modeling the in vivo …

Phase II study of pembrolizumab in combination with doxorubicin in metastatic and unresectable soft-tissue sarcoma

…, CJ Farhangfar, DM Foureau, DM Maxwell… - Clinical Cancer …, 2021 - AACR
Purpose: Doxorubicin is standard therapy for advanced soft-tissue sarcoma (STS) with
minimal improvement in efficacy and increased toxicity with addition of other cytotoxic agents. …

Carboxylesterase: specificity and spontaneous reactivation of an endogenous scavenger for organophosphorus compounds

DM Maxwell, KM Brecht - Journal of Applied Toxicology: An …, 2001 - Wiley Online Library
The ability of carboxylesterase (CaE) to act as a bioscavenger to provide protection against
organophosphorus (OP) compounds has been demonstrated in several animal models. To …

Enzymes as pretreatment drugs for organophosphate toxicity

BP Doctor, L Raveh, AD Wolfe, DM Maxwell… - Neuroscience & …, 1991 - Elsevier
We have successfully demonstrated that exogenously administered acetyl- or butyrylcholinesterase
(AChE, BChE respectively) will sequester organophosphates (OPs) before they …

Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun,

…, SD Kirby, DM Maxwell, PM Potter, DM Cerasoli… - Biochemistry, 2007 - ACS Publications
The organophosphorus nerve agents sarin, soman, tabun, and VX exert their toxic effects by
inhibiting the action of human acetylcholinesterase, a member of the serine hydrolase …