5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years,
increased understanding of the mechanism of action of 5-FU has led to the development of …

Resistance to chemotherapy and molecularly targeted therapies is a major problem facing
current cancer research. The mechanisms of resistance to 'classical' cytotoxic …

Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment. …

Cell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially
harmful cells from within an organism, such as cells with damaged DNA that could lead to …

Purpose Current prognostic factors are poor at identifying patients at risk of disease
recurrence after surgery for stage II colon cancer. Here we describe a DNA microarray–based …

To elucidate mechanisms of resistance to chemotherapies currently used in the first-line
treatment of advanced colorectal cancer, we have developed a panel of HCT116 p53 wild-type (…

Drug resistance is a major factor that limits the effectiveness of chemotherapy. Tumours can
be intrinsically resistant prior to chemotherapy, or resistance may be acquired during …

c-FLIP inhibits caspase 8 activation and apoptosis mediated by death receptors such as Fas
and DR5. We studied the effect of c-FLIP on the apoptotic response to chemotherapies used …

Resistance to chemotherapy is a major obstacle in the treatment of cancer. Despite the advent
of new chemotherapies and molecular-targeted therapies, approximately 90% of patients …

Decentralized identifiers (DIDs) are a new type of identifier that enables verifiable, decentralized
digital identity. A DID identifies any subject (eg, a person, organization, thing, data …