We examine the evidence for free radical involvement and oxidative stress in the pathological
process underlying Parkinson's disease, from postmortem brain tissue. The concept of free …

… Outside of the dopaminergic arena only anticholinergics and the weak N-methyl-d-aspartate
receptor antagonist amantadine have had any use. But these are all symptomatic …

Previously we have shown that cell death in the substantia nigra (SN) in Parkinson's disease
(PD) is associated with an increase in iron content but a decrease in the level of the iron‐…

… absorption bands of the sensitizer, or (d) as thermal energy following a nonradiative transition.
… By summing 1 (HI) 1 A,2 and 1 (N a) 12 over all D and S states we obtain the numerical …

The structure and function of mitochondrial respiratory‐chain enzyme proteins were studied
postmortem in the substantia nigra of nine patients with Parkinson's disease and nine …

A theory is presented for concentration quenching in solid systems, based on the migration
of excitation energy from one activator center to another and eventually to an imperfection …

… basal levels following incubation of tissue homogenates in air alone (D), with 0.01 mM FeSO,
plus 0.25 mM ascorbic acid (E), or with 2 mM FeSO, plus 200 mM H202 (F) at 37OC for 90 …

… Frozen postmortem brain hemispheres from patients with Parkinson’s disease and controls
were dissected as previously described in detail by Dexter et al. (1989). Tissue samples …

… , we demonstrated an increase in basal levels of malondialdehyde, a stable intermediate in
lipid peroxidation, in SN in postmortem brain tissue from patients dying with PD (Dexter et al., …

… zona compacta), putamen, caudate nucleus, globus pallidus, and cerebral cortex (Brodmann
area 10) were dissected from frozen brain according to the technique described by Dexter …