Body weight is tightly regulated physiologically. The recent discovery of the peptide hormone
leptin has permitted more detailed evaluation of the mechanisms responsible for control of …

Obesity is associated with an increased risk of hypertension. In the past 5 years there have
been dramatic advances into the genetic and neurobiological mechanisms of obesity with the …

Selective growth of T lymphocytes occurred when unfractionated normal human bone
marrow cells were cultured with conditioned medium obtained from phytohemagglutinin-…

Leptin is a peptide hormone produced by adipose tissue which acts centrally to decrease
appetite and increase energy expenditure. Although leptin increases norepinephrine turnover …

Thyroid hormones have widespread cellular effects; however it is unclear whether their
effects on the central nervous system (CNS) contribute to global energy balance. Here we …

The mechanism by which pharmacologic administration of the hormone FGF21 increases
energy expenditure to cause weight loss in obese animals is unknown. Here we report that …

Disruptions of the melanocortin signaling system have been linked to obesity. We investigated
a possible role of the central nervous melanocortin system (CNS-Mcr) in the control of …

Leptin plays an important role in regulation of body weight through regulation of food intake
and sympathetically mediated thermogenesis. The hypothalamic melanocortin system, via …

Leptin is an adipocyte-derived hormone that plays a key role in the regulation of body weight
through its actions on appetite and metabolism. Leptin also increases sympathetic nerve …

Estrogens play a major role in the modulation of energy balance through central and
peripheral actions. Here, we demonstrate that central action of estradiol (E2) inhibits AMP-activated …