Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled …
…, JC Smith, I Vaziri, T Healey, Y Rahim, C Luk… - The lancet …, 2017 - thelancet.com
Background ExteNET showed that 1 year of neratinib, an irreversible pan-HER tyrosine
kinase inhibitor, significantly improves 2-year invasive disease-free survival after trastuzumab-…
kinase inhibitor, significantly improves 2-year invasive disease-free survival after trastuzumab-…
[PDF][PDF] Regulation of obesity-related insulin resistance with gut anti-inflammatory agents
…, M Ghazarian, XS Revelo, H Lei, CT Luk… - Cell metabolism, 2015 - cell.com
Obesity has reached epidemic proportions, but little is known about its influence on the
intestinal immune system. Here we show that the gut immune system is altered during high-fat …
intestinal immune system. Here we show that the gut immune system is altered during high-fat …
[HTML][HTML] DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice
Reactive oxygen species (ROS) have been linked to a wide variety of pathologies, including
obesity and diabetes, but ROS also act as endogenous signalling molecules, regulating …
obesity and diabetes, but ROS also act as endogenous signalling molecules, regulating …
In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking
Focal adhesion kinase (FAK) acts as an adaptor at the focal contacts serving as a junction
between the extracellular matrix and actin cytoskeleton. Actin dynamics is known as a …
between the extracellular matrix and actin cytoskeleton. Actin dynamics is known as a …
[HTML][HTML] FAK signalling controls insulin sensitivity through regulation of adipocyte survival
Focal adhesion kinase (FAK) plays a central role in integrin signalling, which regulates growth
and survival of tumours. Here we show that FAK protein levels are increased in adipose …
and survival of tumours. Here we show that FAK protein levels are increased in adipose …
[HTML][HTML] Prospective audit of the use of fresh-frozen plasma, based on Canadian Medical Association transfusion guidelines
C Luk, KM Eckert, RM Barr, IH Chin-Yee - Cmaj, 2002 - Can Med Assoc
Note: INR= international normalized ratio, PTT= activated partial thromboplastin time.* The
160 patients for whom plasma transfusion was inappropriate represented 45% of the patients …
160 patients for whom plasma transfusion was inappropriate represented 45% of the patients …
[HTML][HTML] Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance
…, D Choi, SY Lu, SA Schroer, EP Cai, CT Luk… - Journal of Biological …, 2012 - ASBMB
Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause of chronic liver
disease and is now considered to be the hepatic manifestation of the metabolic syndrome. …
disease and is now considered to be the hepatic manifestation of the metabolic syndrome. …
Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex
L Wang, D Opland, S Tsai, CT Luk, SA Schroer… - Nature Medicine, 2014 - nature.com
Inflammation has a critical role in the development of insulin resistance. Recent evidence
points to a contribution by the central nervous system in the modulation of peripheral …
points to a contribution by the central nervous system in the modulation of peripheral …
Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing
SY Shi, CT Luk, JJ Brunt, T Sivasubramaniyam, SY Lu… - Diabetologia, 2014 - Springer
Aims/hypothesis The growing obesity epidemic necessitates a better understanding of
adipocyte biology and its role in metabolism. The Janus kinase (JAK)–signal transducer and …
adipocyte biology and its role in metabolism. The Janus kinase (JAK)–signal transducer and …
Perforin is a novel immune regulator of obesity-related insulin resistance
…, M Ghazarian, H Tsui, SY Shi, S Schroer, CT Luk… - Diabetes, 2015 - Am Diabetes Assoc
Obesity-related insulin resistance is associated with an influx of pathogenic T cells into visceral
adipose tissue (VAT), but the mechanisms regulating lymphocyte balance in such tissues …
adipose tissue (VAT), but the mechanisms regulating lymphocyte balance in such tissues …
